Complex physiological processes control whether stem cells self-renew, differentiate or
remain quiescent. Two decades of research have placed the Hippo pathway, a highly …

The Hippo pathway and its downstream effectors, the transcriptional co-activators Yes-
associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ) …

The Hippo signaling pathway regulates diverse physiological processes, and its dysfunction
has been implicated in an increasing number of human diseases, including cancer. Here …

Two decades of studies in multiple model organisms have established the Hippo pathway
as a key regulator of organ size and tissue homeostasis. By inhibiting YAP and TAZ …

ABSTRACT YAP and TAZ proteins are transcriptional coactivators encoded by paralogous
genes, which shuttle between the cytoplasm and the nucleus in response to multiple inputs …

Cytokines of the transforming growth factor β (TGF-β) family, including TGF-βs, bone
morphogenic proteins (BMPs), activins, and Nodal, play crucial roles in embryonic …

The transcriptional regulators YAP and TAZ are the focus of intense interest given their
remarkable biological properties in development, tissue homeostasis and cancer. YAP and …

Hippo signaling has been recognized as a key tumor suppressor pathway. Here, we perform
a comprehensive molecular characterization of 19 Hippo core genes in 9,125 tumor …

Background and Aims Cholestatic liver disease is characterized by gut dysbiosis and
excessive toxic hepatic bile acids (BAs). Modification of gut microbiota and repression of BA …

The transcriptional co‐activators YAP (or YAP1) and TAZ (or WWTR1) are frequently
activated during the growth and progression of many solid tumors, including lung, colorectal …