Ketocholesterol (7KC) is a toxic oxysterol that is associated with many diseases and
disabilities of aging, as well as several orphan diseases. 7KC is the most common product of …

Oxysterols are the products of cholesterol oxidation. They have a wide range of effects on
several cells, organs, and systems in the body. Oxysterols also have an influence on the …

Ergothioneine (ET) is a naturally occurring antioxidant that is synthesized by non-yeast fungi
and certain bacteria. ET is not synthesized by animals, including humans, but is avidly taken …

Inflammatory bowel disease (IBD), a general term encompassing Crohn's disease (CD) and
ulcerative colitis (UC), and other conditions, is a chronic and relapsing autoimmune disease …

Abstract Cholesterol-25-hydroxylase (CH25H), the biosynthetic enzyme for 25-
hydroxycholesterol (25HC), is most highly expressed in the lung, but its role in lung biology …

Classic atherosclerosis risk factors do not explain all cases of chronic heart disease. There
is significant evidence that gut microbiota may influence the development of atherosclerosis …

Oxysterols (ie, oxidized cholesterol species) have complex roles in biology. 25-
Hydroxycholesterol (25HC), a product of the activity of cholesterol-25-hydroxylase (CH25H) …

Cholesterol is a member of the sterol family that plays essential roles in biological
processes, including cell membrane stability and myelin formation. Cholesterol can be …

Colorectal cancer (CRC) is the third most common cancer worldwide. Obesity, alcohol
consumption, smoking, high consumption of red or processed meat and a diet with low fibre …

The vascular endothelium forms a barrier that controls flow of solutes and proteins and the
entry of leukocytes into tissue. Injured tissue releases IL-33, which then alarms the immune …