MicroRNAs (miRNAs) are a class of short, non-coding RNAs that function post-
transcriptionally to regulate gene expression by binding to particular mRNA targets and …

Epigenetic mechanisms are essential for normal development and maintenance of tissue-
specific gene expression patterns in mammals. Disruption of epigenetic processes can lead …

Purpose: Testis cancer is the most common solid malignancy in young males. The purpose
of this guideline is to provide a useful reference on the effective evidence-based treatment of …

Limitless cell proliferation, evasion from apoptosis, dedifferentiation, metastatic spread and
therapy resistance: all these properties of a cancer cell contribute to its malignant phenotype …

Two major functions of the mammalian ovary are the production of germ cells (oocytes),
which allow continuation of the species, and the generation of bioactive molecules, primarily …

MicroRNA (miRNAs) are negative regulators of gene expression and can function as tumor
suppressors or oncogenes. Expression patterns of miRNAs and their role in the …

MicroRNAs (miRNAs) encoded by the miR-15/16 cluster are known to act as tumor
suppressors. Expression of these miRNAs inhibits cell proliferation, promotes apoptosis of …

Appropriate patterns of DNA methylation and histone modifications are required to assure
cell identity, and their deregulation can contribute to human diseases, such as cancer. Our …

In the last years, microRNAs (miRNA) have emerged as new molecular players involved in
carcinogenesis. Deregulation of miRNAs expression has been shown in different human …

Epithelial mesenchymal transition (EMT), the adoption by epithelial cells of a mesenchymal-
like phenotype, is a process co-opted by carcinoma cells in order to initiate invasion and …