Chronic obstructive pulmonary disease (COPD) is a devastating lung disease with a high
personal and societal burden. Exposure to toxic particles and gases, including cigarette …

The pathogenesis of chronic obstructive pulmonary disease (COPD) is based on the innate
and adaptive inflammatory immune response to the inhalation of toxic particles and gases …

Background We previously described the contributions of increased total airway mucin
concentrations to the pathogenesis and diagnosis of the chronic bronchitic component of …

Background Chronic obstructive pulmonary disease (COPD) is characterized by chronic
bronchitic and emphysematous components. In one biophysical model, the concentration of …

ABSTRACT COPD is a major global concern, increasingly so in the context of ageing
populations. The role of infections in disease pathogenesis and progression is known to be …

Activating mutations of K-ras are the most common oncogenic alterations found in lung
cancer. Unfortunately, attempts to target K-ras–mutant lung tumors have thus far failed …

Chronic obstructive pulmonary diseases (COPD), comprised of pulmonary emphysema,
chronic bronchitis, and structural and inflammatory changes of small airways, is a leading …

Several convergent destructive mechanisms such as oxidative stress, alveolar cell
apoptosis, extracellular matrix proteolysis and chronic inflammation contribute to chronic …

Tobacco smoking is the most important preventable risk factor for periodontitis; however, the
underlying biological mechanisms responsible for the detrimental effects of smoking on …

Lung cancer is the number one cause of cancer-related deaths. The malignancy is
characterized by dismal prognosis and poor clinical outcome mostly due to advanced-stage …