Invasive lobular carcinoma of the breast is the most common 'special'morphological subtype
of breast cancer, comprising up to 15% of all cases. Tumours are generally of a good …

Breast cancer is a heterogeneous disease, comprising multiple entities associated with
distinctive histological and biological features, clinical presentations and behaviours and …

Understanding cellular metabolism holds immense potential for developing new classes of
therapeutics that target metabolic pathways in cancer. Metabolic pathways are altered in …

Background Validation of a novel gene expression signature in independent data sets is a
critical step in the development of a clinically useful test for cancer patient risk-stratification …

Recent gene expression profiling of breast cancer has identified specific subtypes with
clinical, biologic, and therapeutic implications. The basal-like group of tumors is …

Background MicroRNAs (miRNAs), a class of short non-coding RNAs found in many plants
and animals, often act post-transcriptionally to inhibit gene expression. Results Here we …

To examine the role of breast cancer stem cells (BCSCs) in metastasis, we generated
human-in-mouse breast cancer orthotopic models using patient tumor specimens, labeled …

Abstract Background Centromere Protein F (CENPF) associates with the centromere–
kinetochore complex and influences cell proliferation and metastasis in several cancers. The …

In the last decade, the development of microarrays and the ability to perform massively
parallel gene expression analysis of human tumours were received with great excitement by …

Breast cancer is a complex and heterogeneous disease, comprising multiple tumor entities
associated with distinctive histological patterns and different biological features and clinical …