Semaphorins are extracellular signaling proteins that are essential for the development and
maintenance of many organs and tissues. The more than 20-member semaphorin protein …

The development of the mammalian cerebellum is orchestrated by both cell-autonomous
programs and inductive environmental influences. Here, we describe the main processes of …

Semaphorins are membrane-bound or diffusible factors that regulate key cellular functions
and are involved in cell–cell communication. Most of the effects of semaphorins are …

Granule cells (GCs) are the most numerous cell type in the cerebellum and indeed, in the
brain: at least 99% of all cerebellar neurons are granule cells. In this review article, we first …

Semaphorins, originally discovered as guidance cues for developing axons, are involved in
many processes that shape the nervous system during development, from neuronal …

Semaphorins are key players in the control of neural circuit development. Recent studies
have uncovered several exciting and novel aspects of neuronal semaphorin signalling in …

Neuronal migration is a fundamental process that determines the final allocation of neurons
in the nervous system, establishing the basis for the subsequent wiring of neural circuitry …

Cell-cell signalling of semaphorin ligands through interaction with plexin receptors is
important for the homeostasis and morphogenesis of many tissues and is widely studied for …

Development of neuronal circuits is controlled by evolutionarily conserved axon guidance
molecules, including Slits, the repulsive ligands for roundabout (Robo) receptors, and Netrin …

Plexin transmembrane receptors and their semaphorin ligands, as well as their co-receptors
(Neuropilin, Integrin, VEGFR2, ErbB2, and Met kinase) are emerging as key regulatory …