α2-Adrenergic receptors mediate part of the diverse biological effects of the endogenous
catecholamines epinephrine and norepinephrine. Three distinct subtypes of α2-adrenergic …

Hypertension is a multifactorial disease involving complex interactions between genetic and
environmental factors. Development of experimental models of hypertension allowed …

Mice with altered α2-adrenergic receptor genes have become important tools in elucidating
the subtype-specific functions of the three α2-adrenergic receptor subtypes because of the …

Background—Elevated plasma norepinephrine levels are associated with increased
mortality in patients and in animal models with chronic heart failure. To test which α2 …

From the first description of its anatomy by T. Willis to the novel therapeutic manipulations, it
is unanimously recognized that the sympathetic nervous system (SNS) holds a crucial role in …

Control of blood pressure and of blood flow is essential for maintenance of homeostasis.
The hemodynamic state is adjusted by intrinsic, neural, and hormonal mechanisms to …

α2-Adrenoceptors belong to the group of nine adrenoceptors which mediate the biological
actions of the endogenous catecholamines adrenaline and noradrenaline. Studies with …

This review examines the impact of recent discoveries defining personal genetics of
adrenergic signaling polymorphisms on scientific discovery and medical practice related to …

Genetic manipulation of mice now provides new tools to evaluate the biological functions of
the α2-adrenergic receptor (α2-AR) subtypes (α2A, α2B, and α2C). To investigate the role of …

Essential hypertension is a multifactorial disorder which belongs to the main risk factors
responsible for renal and cardiovascular complications. This review is focused on the …