Orexin‐A and orexin‐B, also named hypocretin‐1 and hypocretin‐2, are two hypothalamic
neuropeptides highly conserved across mammalian species. Their effects are mediated by …

The neuropeptide orexin/hypocretin plays a crucial role in various physiological processes,
including the regulation of sleep/wakefulness, appetite, emotion and the reward system …

FFAR1 is a G-protein-coupled receptor (GPCR) that responds to circulating free fatty acids to
enhance glucose-stimulated insulin secretion and release of incretin hormones. Due to the …

Orexins are a family of neuropeptides that regulate various physiological events, such as
sleep/wakefulness as well as emotional and feeding behavior, and that act on two G-protein …

The orexin system consists of the peptide transmitters orexin-A and-B and the G protein-
coupled orexin receptors OX 1 and OX 2. Orexin receptors are capable of coupling to all four …

Orexin receptors are a family of G protein-coupled receptors that consist of two subtypes:
orexin-1 receptors (OX1Rs) and OX2Rs. They are expressed throughout the central nervous …

A structurally novel class of benzo-or pyrido-fused 1, 3-dihydro-2H-imidazole-2-imines was
designed and evaluated in an inositol phosphate accumulation assay for G q signaling to …

Introduction Narcolepsy is an under-recognized, rare neurologic disorder of
hypersomnolence that is associated with increased mortality and medical and psychiatric co …

Orexin receptors (OX1 receptor and OX2 receptor) are G proteincoupled receptors. A recent
study by Yin et al. 1 was based on the prior proposal that OX2 receptor would couple much …

Orexin neuropeptides have many physiological roles in the sleep-wake cycle, feeding
behavior, reward demands, and stress responses by activating cognitive receptors, the …