Covering 2000 to June 2015 This review discusses the biosynthesis of natural products that
are generated by trans-AT polyketide synthases, a family of catalytically versatile enzymes …

Significant progress has been made in the past four decades toward understanding the
structures and synthesis of bioactive peptides produced by microorganisms through the …

Recent literature on polyketide biosynthesis suggests that polyketide synthases have much
greater diversity in both mechanism and structure than the current type I, II and III paradigms …

The genome of plant-associated Bacillus amyloliquefaciens FZB42 harbors an array of giant
gene clusters involved in synthesis of lipopeptides and polyketides with antifungal …

Many drug candidates from marine and terrestrial invertebrates are suspected metabolites of
uncultured bacterial symbionts. The antitumor polyketides of the pederin family, isolated …

A screening program for bioactive compounds from marine cyanobacteria led to the isolation
of jamaicamides A–C. Jamaicamide A is a novel and highly functionalized lipopeptide …

Although bacterial polyketides are of considerable biomedical interest, the molecular
biology of polyketide biosynthesis in Bacillus spp., one of the richest bacterial sources of …

Covering: up to the end of 2008 This review discusses the biosynthesis of natural products
that are generated by trans-AT polyketide synthases, a family of catalytically versatile …

Modular polyketide synthases (PKSs) are giant bacterial enzymes that synthesize many
polyketides of therapeutic value. In contrast to PKSs that provide acyltransferase (AT) …

The macrocyclic polyketides rapamycin and FK506 are potent immunosuppressants that
prevent T-cell proliferation through specific binding to intracellular protein receptors …