Cancer is one of the leading causes of death worldwide. Chemotherapy and radiotherapy
are the conventional primary treatments for cancer patients. However, most of cancer cells …

The primary source of failure of cancer therapies is multidrug resistance (MDR), which can
be caused by different mechanisms, including the overexpression of ABC transporters in …

Stilbene is an abundant structural scaffold in nature, and stilbene‐based compounds have
been widely reported for their biological activity. Notably,(E)‐resveratrol and its natural …

ATP-binding cassette (ABC) transporters are pivotal for cell detoxification and survival.
Overexpression of ABC transporter in tumor cells lead to chemoresistance through the efflux …

Multidrug resistance (MDR) often leads to a failure of cancer chemotherapy. Breast Cancer
Resistance Protein (BCRP/ABCG2), a member of the superfamily of ATP binding cassette …

Multidrug resistance (MDR) in cancer cells is the development of resistance to a variety of
structurally and functionally nonrelated anticancer drugs. This phenomenon has become a …

ABCG2 plays a major role in anticancer-drug efflux and related tumor multidrug resistance.
Potent and selective ABCG2 inhibitors with low cytotoxicity were investigated among a …

In this short review we report selected examples from recent literature to show the potential
of natural-derived, low molecular weight polyphenols as antitumor agents. The two major …

A series of 13 disubstituted chromones was synthesized. Two types of substituents, on each
side of the scaffold, contributed to both the potency of ABCG2 inhibition and the cytotoxicity …

Chemotherapy is the mainstay in the treatment of breast cancer. However, many drugs that
are commonly used in clinical practice have a high incidence of side effects and multidrug …