The role of insulin resistance and diabetes in nonalcoholic fatty liver disease

H Fujii, N Kawada… - International journal of …, 2020 - mdpi.com
Nonalcoholic fatty liver disease (NAFLD) consists of the entire spectrum of fatty liver disease
in patients without significant alcohol consumption, ranging from nonalcoholic fatty liver …

[HTML][HTML] Novel biomarkers for the management of chronic hepatitis B

T Inoue, Y Tanaka - Clinical and molecular hepatology, 2020 - ncbi.nlm.nih.gov
Hepatitis B virus (HBV) cannot be eliminated completely from infected hepatocytes because
of the presence of intrahepatic covalently closed circular DNA (cccDNA). As chronic hepatitis …

Mac-2 binding protein glycan isomer (M2BPGi) is a new serum biomarker for assessing liver fibrosis: more than a biomarker of liver fibrosis

K Shirabe, Y Bekki, D Gantumur, K Araki, N Ishii… - Journal of …, 2018 - Springer
Assessing liver fibrosis is important for predicting the efficacy of antiviral therapy and patient
prognosis. Liver biopsy is the gold standard for diagnosing liver fibrosis, despite its …

Effect of luseogliflozin on hepatic fat content in type 2 diabetes patients with non‐alcoholic fatty liver disease: a prospective, single‐arm trial (LEAD trial)

Y Sumida, K Murotani, M Saito… - Hepatology …, 2019 - Wiley Online Library
Aims No pharmacological therapies are approved for non‐alcoholic fatty liver disease
(NAFLD). Luseogliflozin, a sodium glucose cotransporter 2 inhibitor, has been developed for …

Skeletal muscle mass influences tolerability and prognosis in hepatocellular carcinoma patients treated with lenvatinib

H Uojima, M Chuma, Y Tanaka, H Hidaka, T Nakazawa… - Liver cancer, 2020 - karger.com
Background: Low skeletal muscle mass is significantly associated with severe adverse
events (AEs) from chemotherapy, and low tolerability leads to decreased survival. We aimed …

Serum Wisteria floribunda agglutinin-positive Mac-2-binding protein level predicts liver fibrosis and prognosis in primary biliary cirrhosis

T Umemura, S Joshita, T Sekiguchi… - Official journal of the …, 2015 - journals.lww.com
OBJECTIVES: Noninvasive markers of liver fibrosis in patients with primary biliary cirrhosis
(PBC) are needed for predicting disease progression. As theWisteria floribundaagglutinin …

Oxidative stress in non-alcoholic fatty liver disease

C Smirne, E Croce, D Di Benedetto, V Cantaluppi… - Livers, 2022 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) is a challenging disease caused by multiple
factors, which may partly explain why it still remains an orphan of adequate therapies. This …

Multiparametric US for identifying patients with high-risk NASH: a derivation and validation study

K Sugimoto, DH Lee, JY Lee, SJ Yu, F Moriyasu… - Radiology, 2021 - pubs.rsna.org
Background Nonalcoholic fatty liver disease (NAFLD) is common in the general population
but identifying patients with high-risk nonalcoholic steatohepatitis (NASH) who are …

Hepatic stellate cells secreting WFA+‐M2BP: Its role in biological interactions with Kupffer cells

Y Bekki, T Yoshizumi, S Shimoda, S Itoh… - Journal of …, 2017 - Wiley Online Library
Abstract Background and Aim Hepatic stellate cells (HSCs) play a central role in hepatic
fibrosis and are regulated by Kupffer cells (KCs). Wisteria floribunda agglutinin‐positive Mac …

[HTML][HTML] Serum biomarkers for liver fibrosis

Z Chen, Y Ma, J Cai, M Sun, L Zeng, F Wu, Y Zhang… - Clinica Chimica …, 2022 - Elsevier
Liver fibrosis is a common pathway in most chronic liver diseases, characterized by
excessive extracellular matrix accumulation. Without treatment, fibrosis will ultimately result …