Microglia, the primary resident immune cell type, constitute a key population of glia in the
retina. Recent evidence indicates that microglia play significant functional roles in the retina …

Age-related macular degeneration (AMD) constitutes a prevalent, chronic, and progressive
retinal degenerative disease of the macula that affects elderly people and cause central …

The molecular pathology of multi-organ injuries in COVID-19 patients remains unclear,
preventing effective therapeutics development. Here, we report a proteomic analysis of 144 …

Inflammation underpins and contributes to the pathogenesis of many retinal degenerative
diseases. The recruitment and activation of both resident microglia and recruited …

Age‐related macular degeneration (AMD) is a common cause of visual impairment in the
elderly. There are very limited therapeutic options for AMD with the predominant therapies …

Microglia, the resident immune cells in the retina and nervous system, make irreplaceable
contributions to the maintenance of normal homeostasis and immune surveillance of these …

Unlike in the healthy mammalian retina, macrophages in retinal degenerative states are not
solely comprised of microglia but may include monocyte-derived recruits. Recent studies …

Microglia are the main resident immune cells of the nervous system and as such they are
involved in multiple roles ranging from tissue homeostasis to response to insults and circuit …

Aging is the greatest risk factor for chronic human diseases, including many eye diseases.
Geroscience aims to understand the effects of the aging process on these diseases …

Dysregulation of the complement system is implicated in neurodegeneration, including
human and animal glaucoma. Optic nerve and retinal damage in glaucoma is preceded by …