Notch signalling links the fate of one cell to that of an immediate neighbour and
consequently controls differentiation, proliferation and apoptotic events in multiple metazoan …

Notch signaling regulates a vast array of crucial developmental processes. It is therefore not
surprising that mutations in genes encoding Notch receptors or ligands lead to a variety of …

Insulin is a major regulator of metabolism in metazoans, including the fruit fly Drosophila
melanogaster. Genome-wide association studies (GWAS) suggest a genetic basis for …

Background Aerobic organisms are susceptible to damage by reactive oxygen species.
Oxidative stress resistance is a quantitative trait with population variation attributable to the …

Tissue stem cells divide to self‐renew and generate differentiated cells to maintain
homeostasis. Although influenced by both intrinsic and extrinsic factors, the genetic …

The Notch signaling pathway controls cell growth, differentiation, and fate decisions, and its
dysregulation has been linked to various human genetic disorders and cancers. To …

The GAL4/UAS binary system has been widely used in Drosophila melanogaster for ectopic
expression of transgenes in a tissue-specific manner. The GMR-GAL4 driver, which …

Notch signaling research dates back to more than one hundred years, beginning with the
identification of the Notch mutant in the fruit fly Drosophila melanogaster. Since then …

Notch signaling involves a highly conserved pathway that mediates communication between
neighboring cells. Activation of Notch by its ligands, results in the release of the Notch …

Notch signaling controls a wide range of cell fate decisions during development and disease
via synergistic interactions with other signaling pathways. Here, through a genome-wide …