Gastrointestinal mucus plays essential roles in modulating interactions between intestinal
lumen contents, including orally delivered drug carriers and the gut microbiome, and …

Introduction Oral administration is the most common route for treating colonic diseases that
present increased incidences in recent years. Colonic mucus is a critical rate-limiting barrier …

The colonic epithelium is comprised of three-dimensional crypts (3D) lined with mucus
secreted by a heterogeneous population of goblet cells. In this study, we report the formation …

Abstract The O-glycoprotein Mucin-2 (MUC2) forms the protective colon mucus layer. While
animal models have demonstrated the importance of Muc2, few studies have explored …

The human colon is home to trillions of microorganisms that modulate gastrointestinal
physiology. The understanding of how this gut ecosystem impacts human health, although …

Introduction Gastrointestinal (GI) in vitro models have received lasting attention as an
effective tool to model drug and nutrient absorption, study GI diseases, and design new drug …

The relationship between the mechanical forces associated with bowel movement and
colonic mucosal physiology is understudied. This is partly due to the limited availability of …

The airway milieu of individuals with muco-obstructive airway diseases (MADs) is defined by
the accumulation of dehydrated mucus due to hyperabsorption of airway surface liquid and …

HIGHLIGHTS•The viscoelastic behavior of human mucus from terminal ileum can be
measured by rheology; airway mucus was used for technical validation.•The viscoelastic …

Dietary fiber-rich foods have been associated with numerous health benefits, including a
reduced risk of cardiovascular and metabolic diseases. Harnessing the potential to deliver …