Background—The goal of this statement is to review available literature and to put forth a
scientific statement on the current practice of fetal cardiac medicine, including the diagnosis …

Autoimmune congenital heart block (CHB) is an immune-mediated acquired disease that is
associated with the placental transference of maternal antibodies specific for Ro and La …

Background Experimental and clinical evidence support the role of macrophage Toll-like
receptor signaling in maternal anti-SSA/Ro–mediated congenital heart block (CHB) …

Disclosures: P. Izmirly reported personal fees from GlaxoSmithKline outside the submitted
work. JP Buyon reported personal fees from Bristol-Myers Squibb LN advisory board …

Autoimmune diseases, with the exception of rheumatoid arthritis and autoimmune thyroiditis,
are individually rare, but together they affect approximately 5 percent of the population in …

Background—A recent case-control study suggested a benefit of hydroxychloroquine (HCQ)
in lowering the risk of cardiac manifestations of neonatal lupus (cardiac-NL) in pregnancies …

Objective: Systemic lupus erythematosus (SLE) is a complex disease with variable
presentations, course and prognosis. We sought to develop evidence-based …

Heterozygous mutations in NKX2. 5, a homeobox transcription factor, were reported to
cause secundum atrial septal defects and result in atrioventricular (AV) conduction block …

Sjogren's syndrome is characterized by the presence of a plethora of autoantibodies (Table
1). We herein review major recent development in autoantibodies associated with Sjogren …

Objective. To assess the true prevalence of con-genital complete heart block (CCHB) in
infants of anti-Ro/SSA–positive women known to have connective tissue disease (CTD) and …