Voltage‐gated calcium channels and their auxiliary subunits: physiology and pathophysiology and pharmacology

AC Dolphin - The Journal of physiology, 2016 - Wiley Online Library
Voltage‐gated calcium channels are essential players in many physiological processes in
excitable cells. There are three main subdivisions of calcium channel, defined by the pore …

Voltage-gated calcium channels

WA Catterall - Cold Spring Harbor perspectives in …, 2011 - cshperspectives.cshlp.org
Voltage-gated calcium (Ca2+) channels are key transducers of membrane potential
changes into intracellular Ca2+ transients that initiate many physiological events. There are …

Structure and Regulation of Voltage-Gated Ca2+ Channels

WA Catterall - Annual review of cell and developmental biology, 2000 - annualreviews.org
▪ Abstract Voltage-gated Ca2+ channels mediate Ca2+ entry into cells in response to
membrane depolarization. Electrophysiological studies reveal different Ca2+ currents …

Molecular physiology of cardiac repolarization

JM Nerbonne, RS Kass - Physiological reviews, 2005 - journals.physiology.org
The heart is a rhythmic electromechanical pump, the functioning of which depends on action
potential generation and propagation, followed by relaxation and a period of refractoriness …

L-Type CaV1.2 Calcium Channels: From In Vitro Findings to In Vivo Function

F Hofmann, V Flockerzi, S Kahl… - Physiological …, 2014 - journals.physiology.org
The L-type Cav1. 2 calcium channel is present throughout the animal kingdom and is
essential for some aspects of CNS function, cardiac and smooth muscle contractility …

Calcium absorption across epithelia

JGJ Hoenderop, B Nilius… - Physiological …, 2005 - journals.physiology.org
Ca2+ is an essential ion in all organisms, where it plays a crucial role in processes ranging
from the formation and maintenance of the skeleton to the temporal and spatial regulation of …

The β Subunit of Voltage-Gated Ca2+ Channels

Z Buraei, J Yang - Physiological reviews, 2010 - journals.physiology.org
Calcium regulates a wide spectrum of physiological processes such as heartbeat, muscle
contraction, neuronal communication, hormone release, cell division, and gene …

Identification and differential subcellular localization of the neuronal class C and class D L-type calcium channel alpha 1 subunits.

JW Hell, RE Westenbroek, C Warner… - The Journal of cell …, 1993 - rupress.org
To identify and localize the protein products of genes encoding distinct L-type calcium
channels in central neurons, anti-peptide antibodies specific for the class C and class D …

T-cell apoptosis detected in situ during positive and negative selection in the thymus

CD Surh, J Sprent - Nature, 1994 - nature.com
BECAUSE of positive and negative selection to molecules of the major histocompatibility
complex (MHC) 1, only a small propor-tion of the massive numbers of T cells generated in …

Calmodulin supports both inactivation and facilitation of L-type calcium channels

RD ZuÈhlke, GS Pitt, K Deisseroth, RW Tsien, H Reuter - Nature, 1999 - nature.com
L-type Ca2+ channels support Ca2+ entry into cells, which triggers cardiac contraction,
controls hormone secretion from endocrine cells and initiates transcriptional events that …