Autophagy and cancer drug resistance in dialogue: pre-clinical and clinical evidence

Y Qin, M Ashrafizadeh, V Mongiardini, B Grimaldi… - Cancer letters, 2023 - Elsevier
The emergence of drug resistance is a major challenge for oncologists. Resistance can be
categorized as acquired or intrinsic; the alteration of several biological mechanisms …

Nanomaterials in tumor immunotherapy: new strategies and challenges

X Zhu, S Li - Molecular Cancer, 2023 - Springer
Tumor immunotherapy exerts its anti-tumor effects by stimulating and enhancing immune
responses of the body. It has become another important modality of anti-tumor therapy with …

Exosomal circRNA: emerging insights into cancer progression and clinical application potential

F Zhang, J Jiang, H Qian, Y Yan, W Xu - Journal of Hematology & …, 2023 - Springer
Exosomal circRNA serves a novel genetic information molecule, facilitating communication
between tumor cells and microenvironmental cells, such as immune cells, fibroblasts, and …

Exosomal circular RNAs: a chief culprit in cancer chemotherapy resistance

X Guo, C Gao, DH Yang, S Li - Drug Resistance Updates, 2023 - Elsevier
Chemotherapy is one of the primary treatments for malignant tumors. However, the acquired
drug resistance hinders clinical efficacy and leads to treatment failure in most patients …

[HTML][HTML] Biological impact and therapeutic perspective of targeting PI3K/Akt signaling in hepatocellular carcinoma: Promises and Challenges

MDA Paskeh, F Ghadyani, M Hashemi… - Pharmacological …, 2023 - Elsevier
Cancer progression results from activation of various signaling networks. Among these,
PI3K/Akt signaling contributes to proliferation, invasion, and inhibition of apoptosis …

Noncoding RNAs as regulators of STAT3 pathway in gastrointestinal cancers: Roles in cancer progression and therapeutic response

M Ashrafizadeh, CD Mohan… - Medicinal research …, 2023 - Wiley Online Library
Gastrointestinal (GI) tumors (cancers of the esophagus, gastric, liver, pancreas, colon, and
rectum) contribute to a large number of deaths worldwide. STAT3 is an oncogenic …

Extracellular vesicles remodel tumor environment for cancer immunotherapy

M Yue, S Hu, H Sun, B Tuo, B Jia, C Chen, W Wang… - Molecular Cancer, 2023 - Springer
Tumor immunotherapy has transformed neoplastic disease management, yet low response
rates and immune complications persist as major challenges. Extracellular vesicles …

[HTML][HTML] Current understanding of plant-derived exosome-like nanoparticles in regulating the inflammatory response and immune system microenvironment

Q Yi, Z Xu, A Thakur, K Zhang, Q Liang, Y Liu… - Pharmacological …, 2023 - Elsevier
Natural compounds are widely used to prevent and treat various diseases due to their
antioxidant and anti-inflammatory effects. As a kind of promising natural compound, plant …

Engineering extracellular vesicles as delivery systems in therapeutic applications

L Wang, D Wang, Z Ye, J Xu - Advanced Science, 2023 - Wiley Online Library
Extracellular vesicles (EVs) are transport vesicles secreted by living cells and released into
the extracellular environment. Recent studies have shown that EVs serve as “messengers” …

Involvement of lncRNAs in cancer cells migration, invasion and metastasis: cytoskeleton and ECM crosstalk

M Ahmad, LB Weiswald, L Poulain, C Denoyelle… - Journal of Experimental …, 2023 - Springer
Cancer is the main cause of death worldwide and metastasis is a major cause of poor
prognosis and cancer-associated mortality. Metastatic conversion of cancer cells is a …