An aversive abstinence syndrome manifests 4–24 h following cessation of chronic use of
nicotine-containing products. Symptoms peak on approximately the 3rd day and taper off …

Introduction The prevalence of tobacco use in the population with schizophrenia is
enormously high. Moreover, nicotine dependence is found to be associated with symptom …

The mu1 opioid receptor gene, OPRM1, has long been a high-priority candidate for human
genetic studies of addiction. Because of its potential functional significance, the non …

In this article, we make the case that social epidemiology provides a useful framework to
define the environment within gene–environment (G× E) research. We describe the …

Background: Recent meta-analyses show strong evidence of associations among genetic
variants in CHRNA5 on chromosome 15q25, smoking quantity, and lung cancer. This meta …

Objective To evaluate the association of nicotinic acetylcholine receptor (nAChR) single
nucleotide polymorphism (SNP) with 7-day point prevalence abstinence (abstinence) in …

Nicotine addiction is highly prevalent in current society and is often comorbid with other
diseases. In the central nervous system, nicotine acts as an agonist for nicotinic …

Despite advances in identifying the genetic basis of psychiatric and neurological disorders,
fundamental questions about their evolutionary origins remain elusive. Here, introgressed …

Alcohol problems represent a classic example of a complex behavioral outcome that is likely
influenced by many genes of small effect. A polygenic approach, which examines aggregate …

Puberty is the developmental window when the final maturation of body systems is
orchestrated by hormones; lifelong sex-related differences and capacity to interact with the …