The formation of functional neural circuits in the vertebrate central nervous system (CNS)
requires that appropriate numbers of the correct types of neuronal and glial cells are …

Type-specific dendrite morphology is a hallmark of the neuron and has important functional
implications in determining what signals a neuron receives and how these signals are …

The study of human cortical development has major implications for brain evolution and
diseases but has remained elusive due to paucity of experimental models. Here we found …

Neurons display extreme degrees of polarization, including compartment-specific organelle
morphology. In cortical, long-range projecting, pyramidal neurons (PNs), dendritic …

Despite extensive research, the current theories on serotonergic dysfunctions and cortisol
hypersecretion do not provide sufficient explanations for the nature of depression. Rational …

Structural genomic variations represent a major driving force of evolution, and a burst of
large segmental gene duplications occurred in the human lineage during its separation from …

Directed neuronal differentiation of human pluripotent stem cells (hPSCs), neural
progenitors, or fibroblasts using transcription factors has allowed for the rapid and highly …

Summary Amyloid-β 1–42 (Aβ42) oligomers are synaptotoxic for excitatory cortical and
hippocampal neurons and might play a role in early stages of Alzheimer's disease (AD) …

The cerebral neocortex is segregated into six horizontal layers, each containing unique
populations of molecularly and functionally distinct excitatory projection (pyramidal) neurons …

Reciprocal deletion and duplication of the 16p11. 2 region is the most common copy number
variation (CNV) associated with autism spectrum disorders. We generated cortical organoids …