Cancer-testis antigens (CTAs) are considered as unique and promising cancer biomarkers
and targets for cancer therapy. CTAs are multifunctional protein group with specific …

Malignant tumors aberrantly overexpress various embryonic genes and proto-oncogenes,
including a variety of cancer-testis antigens (CTAs). CTAs belong to a class of testis-derived …

Purpose: The success of immunotherapy for the treatment of metastatic cancer is contingent
on the identification of appropriate target antigens. Potential targets must be expressed on …

The preferentially expressed antigen of melanoma (PRAME), a cancer-testis antigen with
unknown function, is expressed in many human malignancies and is considered an …

OBJECTIVES: PRAME (Preferentially Expressed Antigen in Melanoma) is a tumor-
associated antigen recognized by immunocytes, and it induces cytotoxic T cell-mediated …

Medulloblastoma is the most frequent malignant childhood brain tumor with a high morbidity.
Identification of new therapeutic targets would be instrumental in improving patient …

BACKGROUND: Myxoid/round cell liposarcoma (MRCL) is the second most common
liposarcoma subtype, accounting for> 33% of liposarcomas and approximately 10% of all …

Background Significant efforts have been made to identify factors that differentiate patients
treated with novel therapies, such as bortezomib in multiple myeloma (MM). The exact …

Bone sarcomas are primary bone tumours found mainly in children and adolescents, as
osteosarcoma and Ewing's sarcoma, and in adults in their 40s as chondrosarcoma. The last …

Abstract Background Deregulation of microRNA (miRNA) transcript levels has been
observed in many types of tumors including osteosarcoma. Molecular pathways regulated …