Clonal hematopoiesis arises from somatic mutations that provide a fitness advantage to
hematopoietic stem cells and the outgrowth of clones of blood cells. Clonal hematopoiesis …

A characteristic feature of terminal erythropoiesis in mammals is extrusion of the highly
condensed nucleus out of the cytoplasm. Other vertebrates, including fish, reptiles …

Gain-of-function mutations activating JAK/STAT signaling are seen in the majority of patients
with myeloproliferative neoplasms (MPN), most commonly JAK2 V617F. Although clinically …

Myelodysplastic syndromes (MDS) are age-related myeloid neoplasms with increased risk
of progression to acute myeloid leukemia (AML). The mechanisms of transformation of MDS …

Objective: The risk of thrombosis in myeloproliferative neoplasms, such as primary
myelofibrosis varies depending on the type of key driving mutation (JAK2 [janus kinase 2] …

Abstract JAK2V617F mutation is associated with an increased risk for athero-thrombotic
cardiovascular disease, but its role in aortic disease development and complications …

Thrombosis, both in arterial and venous territories, is the major complication of
myeloproliferative neoplasms and is responsible for a high rate of morbidity and mortality …

Lipid metabolism is essential for stemness maintenance, self‐renewal, and differentiation of
stem cells, however, the regulatory function of cholesterol metabolism in erythroid …

Cerebral venous sinus thrombosis (CVST) is an uncommon venous thromboembolic event
accounting for< 1% of strokes resulting in brain parenchymal injuries. JAK2 V617F mutation …

Phosphoinositide 3-kinase (PI3K)-AKT and androgen receptor (AR) pathways are commonly
activated in prostate cancers. Their reciprocal regulation makes advanced prostate cancers …