Since the initial discovery of the oncogenic activity of WNT1 in mouse mammary glands, our
appreciation for the complex roles for WNT signalling pathways in cancer has increased …

Pancreatic ductal adenocarcinoma (PDAC) is characterized by near-universal mutations in
KRAS and frequent deregulation of crucial embryonic signalling pathways, including the …

Wnt signaling is one of the key cascades regulating normal tissue development and has
been tightly associated with cancer. The Wnt signaling can be subdivided into two …

Background: The Toll-like receptor (TLR) 4 signalling pathway has been shown to have
oncogenic effects in vitro and in vivo. To demonstrate the role of TLR4 signalling in colon …

Abstract Background 5-Fluorouracil (5-FU) is a widely used drug for the therapy of cancer.
However, the chemoresistance of tumor cells to 5-FU usually limits its clinical effectiveness …

Simple Summary The G2M checkpoint pathway is a critical step in the cell cycle, which is
one of the hallmarks in cancer. We investigated clinical relevance of the G2M pathway in …

Highlights•We review the immune-related hurdles in mRNA-based non-immunogenic
applications.•We suggest some methods to reduce unwanted innate immune …

The investigation of tumor microenvironment (TME) is essential to better characterize the
complex cellular crosstalk and to identify important immunological phenotypes and …

Pancreatic cancer (PC) is one of the most lethal forms of cancer, characterized by its
aggressiveness and metastatic potential. Despite significant improvements in PC treatment …

Bidirectional signal transduction between tumor epithelial cells and tumor microenvironment
(TME) is important for tumor development. Here we show that Lin28b/let-7 pathway is …