SGLT2 inhibitors: mechanisms of cardiovascular benefit beyond glycaemic control

MR Cowie, M Fisher - Nature Reviews Cardiology, 2020 - nature.com
Abstract Sodium–glucose cotransporter 2 (SGLT2) inhibitors are effective antidiabetic
therapies in patients with type 2 diabetes mellitus and are associated with improved …

Adipose tissue dysfunction as determinant of obesity-associated metabolic complications

M Longo, F Zatterale, J Naderi, L Parrillo… - International journal of …, 2019 - mdpi.com
Obesity is a critical risk factor for the development of type 2 diabetes (T2D), and its
prevalence is rising worldwide. White adipose tissue (WAT) has a crucial role in regulating …

Diabesity: the combined burden of obesity and diabetes on heart disease and the role of imaging

ACT Ng, V Delgado, BA Borlaug, JJ Bax - Nature Reviews Cardiology, 2021 - nature.com
Diabesity is a term used to describe the combined adverse health effects of obesity and
diabetes mellitus. The worldwide dual epidemic of obesity and type 2 diabetes is an …

Mechanistic insights of empagliflozin in nondiabetic patients with HFrEF: from the EMPA-TROPISM study

JA Requena-Ibáñez, CG Santos-Gallego… - Heart Failure, 2021 - jacc.org
Objectives The goal of this study was to evaluate the effect of empagliflozin, in addition to
optimal medical treatment, on epicardial adipose tissue (EAT), interstitial myocardial fibrosis …

Atrial fibrillation: epidemiology, pathophysiology, and clinical outcomes

L Staerk, JA Sherer, D Ko, EJ Benjamin… - Circulation …, 2017 - Am Heart Assoc
The past 3 decades have been characterized by an exponential growth in knowledge and
advances in the clinical treatment of atrial fibrillation (AF). It is now known that AF genesis …

Hemodynamic and functional impact of epicardial adipose tissue in heart failure with preserved ejection fraction

KE Koepp, M Obokata, YNV Reddy, TP Olson… - Heart Failure, 2020 - jacc.org
Objectives This study determined the impact of excess epicardial adipose tissue (EAT) in
patients with the obese phenotype of heart failure with preserved ejection fraction (HFpEF) …

Local and systemic effects of the multifaceted epicardial adipose tissue depot

G Iacobellis - Nature Reviews Endocrinology, 2015 - nature.com
Epicardial adipose tissue is a unique and multifaceted fat depot with local and systemic
effects. This tissue is distinguished from other visceral fat depots by a number of anatomical …

[HTML][HTML] Adipose tissue: physiology to metabolic dysfunction

AJ Richard, U White, CM Elks, JM Stephens - Endotext [Internet], 2020 - ncbi.nlm.nih.gov
Like the obesity epidemic, our understanding of adipocytes and adipose tissue is
expanding. Just in the past decade, substantial advances have led to new insights into the …

Human epicardial adipose tissue induces fibrosis of the atrial myocardium through the secretion of adipo-fibrokines

N Venteclef, V Guglielmi, E Balse, B Gaborit… - European heart …, 2015 - academic.oup.com
Aims Recent studies have reported a relationship between the abundance of epicardial
adipose tissue (EAT) and the risk of cardiovascular diseases including atrial fibrillation (AF) …

Inflammaging as a common ground for the development and maintenance of sarcopenia, obesity, cardiomyopathy and dysbiosis

G Livshits, A Kalinkovich - Ageing research reviews, 2019 - Elsevier
Sarcopenia, obesity and their coexistence, obese sarcopenia (OBSP) as well as
atherosclerosis-related cardio-vascular diseases (ACVDs), including chronic heart failure …