Detection of helminths by loop-mediated isothermal amplification assay: a review of updated technology and future outlook

MH Deng, LY Zhong, O Kamolnetr, Y Limpanont… - Infectious diseases of …, 2019 - Springer
Background Helminths are endemic in more than half of the world's countries, raising
serious public health concerns. Accurate diagnosis of helminth infection is crucial to control …

The impact of mosquito sampling strategies on molecular xenomonitoring prevalence for filariasis: a systematic review

LJ Reimer, JD Pryce - Bulletin of the World Health …, 2023 - pmc.ncbi.nlm.nih.gov
Objective To explore the impact of mosquito collection methods, sampling intensity and
target genus on molecular xenomonitoring detection of parasites causing lymphatic …

Colorimetric tests for diagnosis of filarial infection and vector surveillance using non-instrumented nucleic acid loop-mediated isothermal amplification (NINA-LAMP)

CB Poole, Z Li, A Alhassan, D Guelig, S Diesburg… - PloS one, 2017 - journals.plos.org
Accurate detection of filarial parasites in humans is essential for the implementation and
evaluation of mass drug administration programs to control onchocerciasis and lymphatic …

Application of loop mediated isothermal amplification (LAMP) assays for the detection of Onchocerca volvulus, Loa loa and Mansonella perstans in humans and …

GN Amambo, N Innocentia, RA Abong… - Frontiers in tropical …, 2023 - frontiersin.org
Conventional diagnosis of filarial infections is based on morphological identification of
microfilariae using light microscopy and requires considerable expertise, is time-consuming …

Molecular xenomonitoring for post-validation surveillance of lymphatic filariasis in Togo: no evidence for active transmission

MA Dorkenoo, DK de Souza, Y Apetogbo… - Parasites & vectors, 2018 - Springer
Background Lymphatic filariasis (LF) is a mosquito-borne filarial disease targeted for
elimination by the year 2020. The Republic of Togo undertook mass treatment of entire …

Occurrence of L1014F and L1014S mutations in insecticide resistant Culex quinquefasciatus from filariasis endemic districts of West Bengal, India

P Rai, D Saha - PLOS Neglected Tropical Diseases, 2022 - journals.plos.org
Introduction Lymphatic filariasis causes long term morbidity and hampers the socio-
economic status. Apart from the available treatments and medication, control of vector …

The Mbam drainage system and onchocerciasis transmission post ivermectin mass drug administration (MDA) campaign, Cameroon

RA Abong, GN Amambo, AA Hamid… - PLOS Neglected …, 2021 - journals.plos.org
Background The impact of large scale Mass Drug Adminstration (MDA) of ivermectin on
active onchocerciasis transmission by Simulium damnosum, which transmits the parasite O …

Focusing nucleic acid-based molecular diagnostics and xenomonitoring approaches for human helminthiases amenable to preventive chemotherapy

C Minetti, EJ Lacourse, L Reimer, JR Stothard - Parasitology Open, 2016 - cambridge.org
The current mainstay for control of the four major helminth diseases in humans (lymphatic
filariasis, onchocerciasis, soil-transmitted helminthiases and schistosomiasis) is with …

Development of an urban molecular xenomonitoring system for lymphatic filariasis in the Recife Metropolitan Region, Brazil

A Ramesh, M Cameron, K Spence… - PLoS neglected …, 2018 - journals.plos.org
Introduction Molecular xenomonitoring (MX)—pathogen detection in the mosquito rather
than human—is a promising tool for lymphatic filariasis (LF) surveillance. In the Recife …

A case for using genomics and a bioinformatics pipeline to develop sensitive and species-specific PCR-based diagnostics for soil-transmitted helminths

JR Grant, N Pilotte, SA Williams - Frontiers in Genetics, 2019 - frontiersin.org
The balance of expense and ease of use vs. specificity and sensitivity in diagnostic assays
for helminth disease is an important consideration, with expense and ease often winning out …