The immune mechanism of the nasal epithelium in COVID-19–related olfactory dysfunction

S Chen, S Wang - Frontiers in Immunology, 2023 - frontiersin.org
During the first waves of the coronavirus disease 2019 (COVID-19) pandemic caused by
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, olfactory …

Influence of polymorphic variations of IFNL, HLA, and IL-6 genes in severe cases of COVID-19

A Araújo, G Sgorlon, LE Aguiar… - Experimental …, 2023 - journals.sagepub.com
The administration of vaccination doses to the global population has led to a decrease in the
incidence of COVID-19. However, the clinical picture developed by infected individuals …

Genetic association of ACE2 and TMPRSS2 polymorphisms with COVID-19 severity; a single centre study from Egypt

MH Elnagdy, A Magdy, W Eldars, M Elgamal… - Virology Journal, 2024 - Springer
Background Since the emergence of the COVID-19 infection in China, it has caused
considerable morbidity, mortality, and economic burden. It causes the vast majority of clinical …

The Transmembrane protease serine 2 (TMPRSS2) non-protease domains regulating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike …

R Strobelt, J Adler, Y Shaul - Viruses, 2023 - mdpi.com
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) enters cells by binding
to the angiotensin-converting enzyme 2 (hACE2) receptor. This process is aided by the …

Polymorphisms within the SARS-CoV-2 human receptor genes associate with variable disease outcomes across ethnicities

T Adimulam, T Arumugam, A Naidoo, K Naidoo… - Genes, 2023 - mdpi.com
The contribution of human genes to the variability of disease outcomes has been shown to
be important across infectious diseases. Studies have shown mutations within specific …

Quercetin and taxifolin inhibits TMPRSS2 activity and its interaction with EGFR in paclitaxel‐resistant breast cancer cells: An in silico and in vitro study

DB Kundrapu, AK Chaitanya, K Manaswi… - Chemical Biology & …, 2024 - Wiley Online Library
Abstract Transmembrane protease/serine (TMPRSS2), a type II transmembrane serine
protease, plays a crucial role in different stages of cancer. Recent studies have reported that …

The association of rs17713054 with Neanderthal origin at 3p21. 31 locus with the severity of COVID-19 in Iranian patients

M Yaghmouri, J Safdari Lord, M Amini… - Scientific Reports, 2024 - nature.com
Since the COVID-19 pandemic, the diversity of clinical manifestations in patients has been a
tremendous challenge. It seems that genetic variations, as one of the players, contribute to …

Association of specific ACE2 and TMPRSS2 variants with circulatory cytokines of COVID-19 Emirati patients

NM Elemam, A Bouzid, H Alsafar, SBM Ahmed… - Frontiers in …, 2024 - frontiersin.org
Introduction The COVID-19 pandemic represented one of the most significant challenges to
researchers and healthcare providers. Several factors determine the disease severity …

[PDF][PDF] The role of inflammatory gene polymorphisms in severe COVID-19: a review

JQ Yip, A Oo, YL Ng, KL Chin, KK Tan, JJH Chu… - Virology Journal, 2024 - Springer
The COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, has profoundly
impacted global healthcare systems and spurred extensive research efforts over the past …

Evaluation of relationship between TMPRSS2 p.(Val197Met) variant and COVID-19 susceptibility and severity

NAS Bashar, NMAH Gohar, AA Tantawy… - BMC Infectious …, 2024 - Springer
Abstract Background The World Health Organization (WHO) declared Coronavirus Disease
2019 (COVID-19) a global pandemic on March 11, 2020. Severe Acute Respiratory …