Intestinal plasticity and metabolism as regulators of organismal energy homeostasis

O Stojanović, I Miguel-Aliaga, M Trajkovski - Nature metabolism, 2022 - nature.com
The small intestine displays marked anatomical and functional plasticity that includes
adaptive alterations in adult gut morphology, enteroendocrine cell profile and their hormone …

Convergent pathways of the gut microbiota–brain axis and neurodegenerative disorders

C Gubert, J Gasparotto, L H. Morais - Gastroenterology Report, 2022 - academic.oup.com
Recent research has been uncovering the role of the gut microbiota for brain health and
disease. These studies highlight the role of gut microbiota on regulating brain function and …

The Drosophila tumor necrosis factor receptor, Wengen, couples energy expenditure with gut immunity

R Loudhaief, R Jneid, CF Christensen, DJ Mackay… - Science …, 2023 - science.org
It is well established that tumor necrosis factor (TNF) plays an instrumental role in
orchestrating the metabolic disorders associated with late stages of cancers. However, it is …

[HTML][HTML] The Emerging Roles of JNK Signaling in Drosophila Stem Cell Homeostasis

SC Herrera, EA Bach - International Journal of Molecular Sciences, 2021 - mdpi.com
The Jun N-terminal kinase (JNK) pathway is an evolutionary conserved kinase cascade best
known for its roles during stress-induced apoptosis and tumor progression. Recent findings …

[HTML][HTML] Molecular regulation mechanism of intestinal stem cells in mucosal injury and repair in ulcerative colitis

L Zheng, SL Duan - World Journal of Gastroenterology, 2023 - ncbi.nlm.nih.gov
Ulcerative colitis (UC) is a chronic nonspecific inflammatory disease with complex causes.
The main pathological changes were intestinal mucosal injury. Leucine-rich repeat …

[HTML][HTML] Cytoskeletal control and Wnt signaling—APC's dual contributions in stem cell division and colorectal cancer

MA Juanes - Cancers, 2020 - mdpi.com
Simple Summary Colorectal cancer is the third leading cause of cancer death globally. As
well as the adverse health implications for the individual, there are also considerable …

[HTML][HTML] Bacillus thuringiensis Bioinsecticides Induce Developmental Defects in Non-Target Drosophila melanogaster Larvae

MP Nawrot-Esposito, A Babin, M Pasco, M Poirié… - Insects, 2020 - mdpi.com
Simple Summary The use of chemical pesticides is controversial mainly because of their
detrimental effects on both the environment and human health. Public opinion along with …

Regulation and functions of cell division in the intestinal tissue

A Guevara-Garcia, M Soleilhac, N Minc… - Seminars in Cell & …, 2023 - Elsevier
In multicellular organisms, epithelial cells are key elements of tissue organization. In
developing epithelial tissues, cellular proliferation and differentiation are under the tight …

Bacillus thuringiensis toxins divert progenitor cells toward enteroendocrine fate by decreasing cell adhesion with intestinal stem cells in Drosophila

R Jneid, R Loudhaief, N Zucchini-Pascal… - Elife, 2023 - elifesciences.org
Bacillus thuringiensis subsp. kurstaki (Btk) is a strong pathogen toward lepidopteran larvae
thanks to specific Cry toxins causing leaky gut phenotypes. Hence, Btk and its toxins are …

Derlin-1 and TER94/VCP/p97 are required for intestinal homeostasis

F Liu, H Zhao, R Kong, L Shi, Z Li, R Ma… - Journal of Genetics and …, 2022 - Elsevier
Adult stem cells are critical for the maintenance of residential tissue homeostasis and
functions. However, the roles of cellular protein homeostasis maintenance in stem cell …