Alzheimer's therapeutic development: shifting neurodegeneration to neuroregeneration

MK Sun, DL Alkon - Trends in Pharmacological Sciences, 2024 - cell.com
Abstract Alzheimer's disease (AD), similar to AD-related dementias, is characterized by
impaired/lost neuronal structures and functions due to a long progression of …

Reproductive function and behaviors: an update on the role of neural estrogen receptors alpha and beta

T Torres, N Adam, S Mhaouty-Kodja… - Frontiers in …, 2024 - frontiersin.org
Infertility is becoming a major public health problem, with increasing frequency due to
medical, environmental and societal causes. The increasingly late age of childbearing …

Estrogen Regulates Mitochondrial Activity Through Inducing Brain‐Derived Neurotrophic Factor Expression in Skeletal Muscle

MCL Tse, BPS Pang, X Bi, TX Ooi… - Journal of Cellular …, 2024 - Wiley Online Library
Estrogen is an essential hormone for the development and functional activities of
reproductive organs. Recent studies showed that estrogen signaling is also an important …

[HTML][HTML] The Role of Estrogen across Multiple Disease Mechanisms

X Xiang, P Palasuberniam, R Pare - Current Issues in Molecular Biology, 2024 - mdpi.com
Estrogen is a significant hormone that is involved in a multitude of physiological and
pathological processes. In addition to its pivotal role in the reproductive system, estrogen is …

Discovery and functional characterization of LncRNAs associated with inflammation and macrophage activation

A Chini, P Guha, A Rishi, M Obaid, SMN Udden… - Methods, 2024 - Elsevier
Long noncoding RNAs (lncRNA) are emerging players in regulation of gene expression and
cell signaling and their dysregulation has been implicated in a multitude of human diseases …

Expression Profiles of Brain-Derived Neurotrophic Factor Splice Variants in the Hippocampus of Alzheimer's Disease Model Mouse

Y Matsuoka, H Nakasone, R Kasahara… - Biological and …, 2024 - jstage.jst.go.jp
Dysregulation of brain-derived neurotrophic factor (BDNF) has been implicated in
Alzheimer's disease (AD). In this study, we investigated the temporal dynamics of BDNF …