Apoptosis, a form of programmed cell death, is responsible for eliminating damaged or
unnecessary cells in multicellular organisms. Various types of intracellular stress trigger …

Segregation of the replicated genome during cell division in eukaryotes requires the
kinetochore to link centromeric DNA to spindle microtubules. The kinetochore is composed …

The microtubule-based spindle orchestrates chromosome segregation during cell division.
Following more than a century of study, many components and pathways contributing to …

During eukaryotic cell division, the sister chromatids of duplicated chromosomes are pulled
apart by microtubules, which connect via kinetochores. The kinetochore is a multiprotein …

In eukaryotic cells, the spatial segregation of replication and transcription in the nucleus and
translation in the cytoplasm imposes the requirement of transporting thousands of …

Cell division in eukaryotes requires extensive architectural changes of the nuclear envelope
(NE) to ensure that segregated DNA is finally enclosed in a single cell nucleus in each …

Nuclear pore complexes (NPCs) are huge protein assemblies within the nuclear envelope
(NE) that serve as selective gates for macromolecular transport between nucleus and …

Nuclear pore complexes (NPCs) are indispensable for cell function and are at the center of
several human diseases. NPCs provide access to the nucleus and regulate the transport of …

The nuclear envelope (NE) is a highly regulated membrane barrier that separates the
nucleus from the cytoplasm in eukaryotic cells. It contains a large number of different …

Abstract The small nuclear GTPase Ran controls the directionality of macromolecular
transport between the nucleus and the cytoplasm. Ran also has important roles during …