Discovery and development of biopeptides are time‐consuming, laborious, and dependent
on various factors. Data‐driven computational methods, especially machine learning (ML) …

In recent years, the advent of new experimental methodologies for studying the high
complexity of the human genome and proteome has led to the generation of an increasing …

N6-methyladenosine (m 6 A) modification is the most abundant RNA methylation
modification and involves various biological processes, such as RNA splicing and …

Drug-induced hepatotoxicity may cause acute and chronic liver disease, leading to great
concern for patient safety. It is also one of the main reasons for drug withdrawal from the …

Biomimetic nanoparticles are known to serve as nanoscale adjuvants, enzyme mimics and
amyloid fibrillation inhibitors. Their further development requires better understanding of …

Gram-negative bacteria use various secretion systems to deliver their secreted effectors.
Among them, type IV secretion system exists widely in a variety of bacterial species, and …

DNA N 4-methylcytosine (4mC) is one of the key epigenetic alterations, playing essential
roles in DNA replication, differentiation, cell cycle, and gene expression. To better …

Background Pseudouridylation is the most prevalent type of posttranscriptional modification
in various stable RNAs of all organisms, which significantly affects many cellular processes …

Identification of hot spots, a small portion of protein-protein interface residues that contribute
the majority of the binding free energy, can provide crucial information for understanding the …

Hot spots are the subset of interface residues that account for most of the binding free
energy, and they play essential roles in the stability of protein binding. Effectively identifying …