The workshop entitled 'Interventions to Slow Aging in Humans: Are We Ready?'was held in
Erice, Italy, on October 8–13, 2013, to bring together leading experts in the biology and …

The T arget of R apamycin (TOR or mTOR) is a serine/threonine kinase that regulates
growth, development, and behaviors by modulating protein synthesis, autophagy, and …

There exists a phenomenon in aging research whereby early life stress can have positive
impacts on longevity. The mechanisms underlying these observations suggest a robust, long …

Insulin/insulin-like growth factor (IGF)-1 signaling (IIS) pathway regulates aging in many
organisms, ranging from simple invertebrates to mammals, including humans. Many seminal …

Background The heat shock response, induced by cytoplasmic proteotoxic stress, is one of
the most highly conserved transcriptional responses. This response, driven by the heat …

The maintenance of cellular and organismal homeostasis in the face of changes in the
environment is essential for survival. Pathogenic microorganisms represent one type of …

Cellular metabolism is regulated by the mTOR kinase, a key component of the molecular
nutrient sensor pathway that plays a central role in cellular survival and aging. The mTOR …

Lonicera japonica (LJ) is widely used as the local medicine to improve body and prevent ills
in China, but mechanisms of its healthy beneficial effects remain largely unclear. Here, we …

Ageing is a complex and multifactorial process characterized by the accumulation of many
forms of damage at the molecular, cellular, and tissue level with advancing age. Ageing …

In this work, we examine the relationship between stress resistance and aging. We find that
resistance to multiple types of stress peaks during early adulthood and then declines with …