Optimization and mechanisms of proteolytic enzyme immobilization onto large-pore mesoporous silica nanoparticles: Enhanced tumor penetration

N Qiu, QY Lv, CL Li, X Song, YQ Wang, J Chen… - International Journal of …, 2024 - Elsevier
Immobilization of proteolytic enzymes onto nanocarriers is effective to improve drug diffusion
in tumors through degrading the dense extracellular matrix (ECM). Herein, immobilization …

The impact of ligands on the structure and flexibility of sulfotransferases: a molecular dynamics simulation study

L Zhao, P Zhang, S Long, L Wang, P Tian - Journal of molecular modeling, 2015 - Springer
Sulfotransferases catalyze transfer of the sulfuryl-group (-SO 3) from 3′-phosphoadenosine
5′-phosphosulfate (PAPS) to a large number of substrates. They play an important role in …