Cancer is a leading cause of death worldwide. Identifying the best treatment using
computational models to personalize drug response prediction holds great promise to …

In-depth modeling of the complex interplay among multiple omics data measured from
cancer cell lines or patient tumors is providing new opportunities toward identification of …

FOXM1 is frequently overexpressed in cancer, but this has not been studied in a
comprehensive manner. We utilized genotype-tissue expression (GTEx) normal and The …

Resistance to therapy remains a major cause of cancer treatment failures, resulting in many
cancer-related deaths. Resistance can occur at any time during the treatment, even at the …

Motivation Individualized drug response prediction is a fundamental part of personalized
medicine for cancer. Great effort has been made to discover biomarkers or to develop …

In 2013, we published a comparative analysis of mutation and gene expression profiles and
drug sensitivity measurements for 15 drugs characterized in the 471 cancer cell lines …

Background Emerging studies have revealed the potent functions of circRNAs in breast
cancer tumorigenesis. However, the biogenesis, biofunction and mechanism of circRNAs in …

Highlights•RNA-seq is emerging as a powerful technology to study alternative splicing.•RNA
mis-splicing can cause cancers and a variety of other human diseases.•To target alternative …

Abstract CellMiner (http://discover. nci. nih. gov/cellminer) and CellMinerCDB
(https://discover. nci. nih. gov/cellminercdb/) are web-based applications for mining publicly …

TTK protein kinase (TTK), also known as Monopolar spindle 1 (MPS1), is a key regulator of
the spindle assembly checkpoint (SAC), which functions to maintain genomic integrity. TTK …