Melanoma is a cutaneous neoplastic growth of melanocytes with great potential to invade
and metastasize, especially when not treated early and effectively. Epithelial-mesenchymal …

Simple Summary Metastatic melanoma has poor survival rates in comparison to other types
of skin cancer. Traditional therapies are not very effective in treating advanced melanoma …

Purpose Amplifications and mutations in the KIT proto-oncogene in subsets of melanomas
provide therapeutic opportunities. Patients and Methods We conducted a multicenter phase …

Skin cancers are among the most common cancers worldwide and are increasingly
prevalent. Cutaneous melanoma (CM) is characterized by the malignant transformation of …

Activating mutations in RAS genes are the most common genetic driver of human cancers.
Yet, drugging this small GTPase has proven extremely challenging and therapeutic …

Melanoma can be stratified into unique subtypes based on distinct pathologies. The
acral/mucosal melanoma subtype is characterized by aberrant and constitutive activation of …

Melanoma is the least common form of skin cancer, but it is responsible for the majority of
skin cancer deaths. Traditional therapeutics and immunomodulatory agents have not shown …

The American Joint Committee on Cancer staging system for cutaneous melanoma is based
on primary tumor thickness and the presence of ulceration, mitoses, lymph node spread, and …

Triple-negative breast cancer (TNBC) is associated with a poor prognosis and the absence
of targeted therapy. c-Kit, a receptor tyrosine kinase (RTK), is considered a molecular target …

Melanoma and non-melanoma skin cancers (NMSCs) are the most frequent cancers of the
skin in white populations. An increased risk in the development of skin cancers has been …