Autophagy is a lysosomal degradation process and protective housekeeping mechanism to
eliminate damaged organelles, long-lived misfolded proteins and invading pathogens …

Autophagy is a lysosomal degradative process used to recycle obsolete cellular constituents
and eliminate damaged organelles and protein aggregates. These substrates reach …

Lysosomes, single-membrane organelles defined by a uniquely strong acidic lumenal pH
and high content of acid hydrolases, are the shared degradative compartments of the …

Over the past 20 years, the concept of mammalian autophagy as a nonselective degradation
system has been repudiated, due in part to important discoveries in neurodegenerative …

Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disorder affecting
motor neurons, resulting in progressive muscle weakness and death by respiratory failure …

Protein aggregation is a continuous process in our cells. Some proteins aggregate in a
regulated manner required for different vital functional processes in the cells whereas other …

In autophagy long‐lived proteins, protein aggregates or damaged organelles are engulfed
by vesicles called autophagosomes prior to lysosomal degradation. Autophagy dysfunction …

Macroautophagy, a major pathway for organelle and protein turnover, has been implicated
in the neurodegeneration of Alzheimer's disease (AD). The basis for the profuse …

Alzheimer's disease (AD) is the most common type of dementia which characterized by a
progressive loss of memory and cognitive function due to degeneration of synapses and …

Autophagy is a potent intracellular degradation process with pivotal roles in health and
disease. Atg8, a lipid-conjugated ubiquitin-like protein, is required for the formation of …