Proteoglycan chemical diversity drives multifunctional cell regulation and therapeutics
The extracellular matrix (ECM) constitutes a highly dynamic three-dimensional structural
network comprised of macromolecules, such as proteoglycans/glycosaminoglycans …
network comprised of macromolecules, such as proteoglycans/glycosaminoglycans …
[HTML][HTML] Heparan sulfate proteoglycans biosynthesis and post synthesis mechanisms combine few enzymes and few core proteins to generate extensive structural and …
Glycosylation is a common and widespread post-translational modification that affects a
large majority of proteins. Of these, a small minority, about 20, are specifically modified by …
large majority of proteins. Of these, a small minority, about 20, are specifically modified by …
[HTML][HTML] Comprehensive structural assignment of glycosaminoglycan oligo-and polysaccharides by protein nanopore
P Bayat, C Rambaud, B Priem, M Bourderioux… - Nature …, 2022 - nature.com
Glycosaminoglycans are highly anionic functional polysaccharides with information content
in their structure that plays a major role in the communication between the cell and the …
in their structure that plays a major role in the communication between the cell and the …
Sweet but Challenging: Tackling the Complexity of GAGs with Engineered Tailor‐Made Biomaterials
J Le Pennec, C Picart, RR Vivès… - Advanced …, 2024 - Wiley Online Library
Glycosaminoglycans (GAGs) play a crucial role in tissue homeostasis by regulating the
activity and diffusion of bioactive molecules. Incorporating GAGs into biomaterials has …
activity and diffusion of bioactive molecules. Incorporating GAGs into biomaterials has …
The sweet spot: how GAGs help chemokines guide migrating cells
Y Monneau, F Arenzana-Seisdedos… - Journal of Leucocyte …, 2016 - academic.oup.com
Glycosaminoglycans are polysaccharides that occur both at the cell surface and within
extracellular matrices. Through their ability to bind to a large array of proteins, almost 500 of …
extracellular matrices. Through their ability to bind to a large array of proteins, almost 500 of …
Perlecan, a modular instructive proteoglycan with diverse functional properties
J Melrose - The International Journal of Biochemistry & Cell …, 2020 - Elsevier
This study reviewed some new aspects of the modular proteoglycan perlecan, a colossal
proteoglycan with a 467 kDa core protein and five distinct functional domains. Perlecan is a …
proteoglycan with a 467 kDa core protein and five distinct functional domains. Perlecan is a …
Fell–Muir lecture: heparan sulphate and the art of cell regulation: a polymer chain conducts the protein orchestra
J Gallagher - International journal of experimental pathology, 2015 - Wiley Online Library
Heparan sulphate (HS) sits at the interface of the cell and the extracellular matrix. It is a
member of the glycosaminoglycan family of anionic polysaccharides with unique structural …
member of the glycosaminoglycan family of anionic polysaccharides with unique structural …
Discovery of a fucoidan endo-4O-sulfatase: Regioselective 4O-desulfation of fucoidans and its effect on anticancer activity in vitro
AS Silchenko, AB Rasin, AO Zueva, MI Kusaykin… - Carbohydrate …, 2021 - Elsevier
Fucoidans are a class of sulfated fucose-containing bioactive polysaccharides produced by
brown algae. The biological effects exhibited by fucoidans are thought to be related to their …
brown algae. The biological effects exhibited by fucoidans are thought to be related to their …
The “in and out” of glucosamine 6-O-sulfation: the 6th sense of heparan sulfate
R El Masri, A Seffouh, H Lortat-Jacob, RR Vivès - Glycoconjugate journal, 2017 - Springer
The biological properties of Heparan sulfate (HS) polysaccharides essentially rely on their
ability to bind and modulate a multitude of protein ligands. These interactions involve …
ability to bind and modulate a multitude of protein ligands. These interactions involve …
[HTML][HTML] Post-synthetic regulation of HS structure: the yin and yang of the sulfs in cancer
RR Vivès, A Seffouh, H Lortat-Jacob - Frontiers in oncology, 2014 - frontiersin.org
Heparan sulfate (HS) is a complex polysaccharide that takes part in most major cellular
processes, through its ability to bind and modulate a very large array of proteins. These …
processes, through its ability to bind and modulate a very large array of proteins. These …