The extracellular matrix (ECM) constitutes a highly dynamic three-dimensional structural
network comprised of macromolecules, such as proteoglycans/glycosaminoglycans …

Glycosylation is a common and widespread post-translational modification that affects a
large majority of proteins. Of these, a small minority, about 20, are specifically modified by …

Glycosaminoglycans are highly anionic functional polysaccharides with information content
in their structure that plays a major role in the communication between the cell and the …

Glycosaminoglycans (GAGs) play a crucial role in tissue homeostasis by regulating the
activity and diffusion of bioactive molecules. Incorporating GAGs into biomaterials has …

Glycosaminoglycans are polysaccharides that occur both at the cell surface and within
extracellular matrices. Through their ability to bind to a large array of proteins, almost 500 of …

This study reviewed some new aspects of the modular proteoglycan perlecan, a colossal
proteoglycan with a 467 kDa core protein and five distinct functional domains. Perlecan is a …

Heparan sulphate (HS) sits at the interface of the cell and the extracellular matrix. It is a
member of the glycosaminoglycan family of anionic polysaccharides with unique structural …

Fucoidans are a class of sulfated fucose-containing bioactive polysaccharides produced by
brown algae. The biological effects exhibited by fucoidans are thought to be related to their …

The biological properties of Heparan sulfate (HS) polysaccharides essentially rely on their
ability to bind and modulate a multitude of protein ligands. These interactions involve …

Heparan sulfate (HS) is a complex polysaccharide that takes part in most major cellular
processes, through its ability to bind and modulate a very large array of proteins. These …