Genetic and biochemical analyses of the secretory pathway have produced a detailed
picture of the molecular mechanisms involved in selective cargo transport between …

The microvascular endothelial cell monolayer localized at the critical interface between the
blood and vessel wall has the vital functions of regulating tissue fluid balance and supplying …

Deregulation of Akt/protein kinase B (PKB) is implicated in the pathogenesis of cancer and
diabetes. Akt/PKB activation requires the phosphorylation of Thr308 in the activation loop by …

Membrane fusion, one of the most fundamental processes in life, occurs when two separate
lipid membranes merge into a single continuous bilayer. Fusion reactions share common …

The exocyst is an octameric protein complex that is implicated in the tethering of secretory
vesicles to the plasma membrane prior to SNARE-mediated fusion. Spatial and temporal …

Intracellular membrane fusion is mediated in most cases by membrane-bridging complexes
of soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) …

Vesicle fusion involves vesicle tethering, docking, and membrane merger. We show that
mitofusin, an integral mitochondrial membrane protein, is required on adjacent mitochondria …

Vesicular/membrane trafficking essentially regulates the compartmentalization and
abundance of proteins within the cells and contributes in many signalling pathways. This …

▪ Abstract The endoplasmic reticulum (ER) and the Golgi comprise the first two steps in
protein secretion. Vesicular carriers mediate a continuous flux of proteins and lipids between …

The fusion of transport vesicles with their target membranes is fundamental for intracellular
membrane trafficking and diverse physiological processes and is driven by the assembly of …