Glaucoma is a leading cause of irreversible blindness worldwide. Primary open-angle
glaucoma (POAG), the most common type, is a complex inherited disorder that is …

Glaucoma, a progressive degenerative condition that results in the death of retinal ganglion
cells, is one of the leading causes of blindness, affecting millions worldwide. The …

Upon heterologous overexpression, many proteins misfold or aggregate, thus resulting in
low functional yields. Human acetylcholinesterase (hAChE), an enzyme mediating synaptic …

Latrophilins, receptors for spider venom α-latrotoxin, are adhesion type G-protein-coupled
receptors with emerging functions in synapse development. The N-terminal region binds the …

Olfactomedin (OLF) domain-containing proteins play roles in fundamental cellular processes
and have been implicated in disorders ranging from glaucoma, cancers and inflammatory …

Primary open angle glaucoma (POAG) is a common late-onset neurodegenerative disease.
Ocular hypertension represents a major risk factor, but POAG etiology remains poorly …

Mutations in the gene MYOC account for approximately 5% of cases of primary open angle
glaucoma (POAG). MYOC encodes for the protein myocilin, a multimeric secreted …

A major drainage network involved in aqueous humor dynamics is the conventional outflow
pathway, which is gated by the trabecular meshwork (TM). The TM acts as a molecular …

Conspectus Numerous human disorders arise due to the inability of a particular protein to
adopt its correct three-dimensional structure in the context of the cell, leading to aggregation …

Studies of folded-to-misfolded transitions using model protein systems reveal a range of
unfolding needed for exposure of amyloid-prone regions for subsequent fibrillization. Here …