Adenosine deaminase (ADA) is an enzyme of purine metabolism that irreversibly converts
adenosine to inosine or 2′ deoxyadenosine to 2′ deoxyinosine. ADA is active both inside …

There is increasing evidence for a link between inflammation and thrombosis. Following
tissue injury, vascular endothelium becomes activated, losing its antithrombotic properties …

Background Nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR) are
effective substrates for NAD synthesis, which may act as vasoprotective agents. Here, we …

Endothelial cells are a preferential target for SARS-CoV-2 infection. Previously, we have
reported that vascular adenosine deaminase 1 (ADA1) may serve as a biomarker of …

Purpose Aortic valve disease (AVD) affects millions of people around the world, with no
pharmacological intervention available. Widely considered a multi-faceted disease …

Background CAVD (calcific aortic valve disease) involves an inflammatory response similar
to pyroptosis; therefore, we speculated that the progression of pyroptosis might be involved …

Hypercholesterolemia affects the neurovascular unit, including the cerebral blood vessel
endothelium. Operation of this system, especially in the context of energy metabolism, is …

Arterial calcification, the deposition of calcium-phosphate crystals in the extracellular matrix,
resembles physiological bone mineralization. It is well-known that extracellular nucleotides …

A significant amount of knowledge has been gained with the use of cell-based assays to
elucidate the mechanisms that mediate heart valve calcification. However, cells used in …

The vascular endothelium is key target for immune and thrombotic responses that has to be
controlled in successful xenotransplantation. Several genes were identified that, if induced …