Human spermatogonia are target for exploration of adult stem cell characteristics and
potential source for the development of therapeutic applications. Almost 50 years ago, Yves …

We hypothesised that antenatal exposure to ubiquitous phthalates may lead to an earlier
menarche and a lower prevalence of polycystic ovarian syndrome (PCOS) and polycystic …

In the testis, a subset of spermatogonia retains stem cell potential, while others differentiate
to eventually become spermatozoa. This delicate balance must be maintained, as defects …

Spermatogonial stem cells (SSCs) are a subset of undifferentiated spermatogonia
responsible for ongoing spermatogenesis in mammalian testes. Spermatogonial stem cells …

Spermatogonial stem cells (SSCs) must balance self-renewal with production of transit-
amplifying progenitors that differentiate in response to retinoic acid (RA) before entering …

In the mammalian testis, sustained spermatogenesis relies on spermatogonial stem cells
(SSCs); their progeny either remain as stem cells (self-renewal) or proliferate and …

Continual sperm production relies on germ cells undergoing spermatogenesis
asynchronously. As a result, the testis always contains a mixed population of germ cells at …

Isolating discrete populations of germ cells from the mouse testis is challenging, because
the adult testis contains germ cells at every step of spermatogenesis, in addition to somatic …

In mammals, most neonatal male germ cells (prospermatogonia) are quiescent and located
in the center of the testis cords. In response to an unknown signal, prospermatogonia …

Tissue development and homeostasis are dependent on highly regulated gene expression
programs in which cell-specific combinations of regulatory factors determine which genes …