Mitochondria are one of the most exhaustively investigated organelles in the cell and most
attention has been paid to the components of the mitochondrial electron transport chain …

Cardiolipin (CL) is a key phospholipid of the mitochondria. A loss of CL content and
remodeling of CL's acyl chains is observed in several pathologies. Strong shifts in CL …

Abstract The EMPA-REG OUTCOME (Empagliflozin, Cardiovascular Outcome Event Trial in
patients with Type 2 Diabetes Mellitus (T2DM)) trial made evident the potentiality of …

Fibroblasts from patients with Tangier disease carrying ATP-binding cassette A1 (ABCA1)
loss-of-function mutations are characterized by cardiolipin accumulation, a mitochondrial …

Rationale: Mitochondrial dysfunction facilitates heart failure development forming a
therapeutic target, but the mechanism involved remains unclear. We studied whether the …

Mitochondrial dysfunction contributes to cardiac pathologies. Barriers to new therapies
include an incomplete understanding of underlying molecular culprits and a lack of effective …

Acute pancreatitis (AP) is one of the common acute abdominal inflammatory diseases in
clinic with acute onset and rapid progress. About 20% of the patients will eventually develop …

Nonalcoholic fatty liver disease (NAFLD) is the most common chronic fatty liver disease
worldwide, particularly in obese and type 2 diabetic individuals. Currently, there are no …

Exercise capacity is a strong predictor of all-cause mortality. Skeletal muscle mitochondrial
respiratory capacity, its biggest contributor, adapts robustly to changes in energy demands …

Mitochondria are the energy-producing organelles within a cell. Furthermore, mitochondria
have a role in maintaining cellular homeostasis and proper calcium concentrations, building …