The aetiology of systemic lupus erythematosus (SLE) is multifactorial, and includes
contributions from the environment, stochastic factors, and genetic susceptibility. Great gains …

Investigations of patients with systemic lupus erythematosus have applied insights from
studies of the innate immune response to define IFN-I, with IFN-α as the dominant mediator …

Type I interferons, which make up the first cytokine family to be described and are the
essential mediators of antivirus host defense, have emerged as central elements in the …

Monocytes undergo phenotypic and functional changes in response to inflammatory cues,
but the molecular signals that drive different monocyte states remain largely undefined. We …

Ectopic lymphoid neogenesis often occurs in the target tissues of patients with chronic
rheumatic autoimmune diseases such as rheumatoid arthritis, Sjögren syndrome and other …

Lupus nephritis remains one of the most severe manifestations of systemic lupus
erythematosus associated with considerable morbidity and mortality. A better understanding …

Obesity has been implicated in the rise of autoimmunity in women. We report that obesity
induces a serum protein signature that is associated with T helper 1 (Th1), interleukin (IL) …

SLE is an autoimmune inflammatory disease in which various pro‐and anti‐inflammatory
cytokines, including TGF‐β, IL‐10, BAFF, IL‐6, IFN‐α, IFN‐γ, IL‐17, and IL‐23, play crucial …

Objective The NLRP3 inflammasome plays key roles in inflammation and autoimmunity, and
purinergic receptor P2X7 has been proposed to be upstream of NLRP3 activation. The aim …

Bone remodeling is a lifelong process in vertebrates that relies on the correct balance
between bone resorption by osteoclasts and bone formation by osteoblasts. Bone loss and …