Strengths, weaknesses, opportunities and challenges for long acting injectable therapies: Insights for applications in HIV therapy
A Owen, S Rannard - Advanced drug delivery reviews, 2016 - Elsevier
Advances in solid drug nanoparticle technologies have resulted in a number of long-acting
(LA) formulations with the potential for once monthly or longer administration. Such …
(LA) formulations with the potential for once monthly or longer administration. Such …
Rapidly separable microneedle patch for the sustained release of a contraceptive
Women often have limited access to contraception, and barrier methods have low
acceptance and a high failure rate, mostly due to incorrect use, which can result in …
acceptance and a high failure rate, mostly due to incorrect use, which can result in …
Advances in controlled release hormonal technologies for contraception: A review of existing devices, underlying mechanisms, and future directions
S Sivasankaran, S Jonnalagadda - Journal of Controlled Release, 2021 - Elsevier
This article presents a comprehensive review on controlled release hormonal contraceptive
systems that include transdermal patches, intravaginal rings (IVRs), intrauterine devices …
systems that include transdermal patches, intravaginal rings (IVRs), intrauterine devices …
Biodegradable polymeric injectable implants for long‐term delivery of contraceptive drugs
OS Manoukian, MR Arul, N Sardashti… - Journal of applied …, 2018 - Wiley Online Library
Development of injectable, long‐lasting, contraceptive drug delivery formulations, and
implants are highly desired to avoid unplanned pregnancies while improving patient …
implants are highly desired to avoid unplanned pregnancies while improving patient …
Long-acting injectables: current perspectives and future promise
K Chaudhary, MM Patel… - Critical Reviews™ in …, 2019 - dl.begellhouse.com
The parenteral route of administration is preferred over the oral route for treatment of many
chronic and life-threatening diseases due to better patient compliance. Long-acting …
chronic and life-threatening diseases due to better patient compliance. Long-acting …
Dissolving microneedles loaded with etonogestrel microcrystal particles for intradermal sustained delivery
M He, G Yang, S Zhang, X Zhao, Y Gao - Journal of Pharmaceutical …, 2018 - Elsevier
The study design is that lipophilic drug was encapsulated within dissolving microneedles
(DMNs) for sustained-release delivery over 1 week. Etonogestrel (ENG), the progestogen …
(DMNs) for sustained-release delivery over 1 week. Etonogestrel (ENG), the progestogen …
Beyond conventional antibiotics—New directions for combination products to combat biofilm
DF Bayramov, JA Neff - Advanced drug delivery reviews, 2017 - Elsevier
Medical device related infections are a significant and growing source of morbidity and
mortality. Biofilm formation is a common feature of medical device infections that is not …
mortality. Biofilm formation is a common feature of medical device infections that is not …
Exploring Trehalose on the release of levonorgestrel from implantable PLGA microneedles
X Zhao, S Zhang, G Yang, Z Zhou, Y Gao - Polymers, 2020 - mdpi.com
Hydrophobic drugs wrapped in poly (lactic-co-glycolic acid)(PLGA)-based microneedles
(MNs) require a long time to release completely. To obtain the desired duration, it is still …
(MNs) require a long time to release completely. To obtain the desired duration, it is still …
BEPO®: bioresorbable diblock mPEG-PDLLA and triblock PDLLA-PEG-PDLLA based in situ forming depots with flexible drug delivery kinetics modulation
C Roberge, JM Cros, J Serindoux, ME Cagnon… - Journal of Controlled …, 2020 - Elsevier
This article presents BEPO®, an in situ forming depot (ISFD) technology mediated by a
solvent-exchange mechanism. The matrix of the in situ formed drug delivery depot is …
solvent-exchange mechanism. The matrix of the in situ formed drug delivery depot is …
A once-a-month oral contraceptive
AR Kirtane, T Hua, A Hayward, A Bajpayee… - Science Translational …, 2019 - science.org
Poor patient adherence to oral contraceptives is the predominant cause of failure of these
therapies, leading to unplanned pregnancies that can negatively affect female health …
therapies, leading to unplanned pregnancies that can negatively affect female health …