Neuroblastoma pathogenesis: deregulation of embryonic neural crest development
Neuroblastoma (NB) is an aggressive pediatric cancer that originates from neural crest
tissues of the sympathetic nervous system. NB is highly heterogeneous both from a clinical …
tissues of the sympathetic nervous system. NB is highly heterogeneous both from a clinical …
[HTML][HTML] The sympathoadrenal cell lineage: specification, diversification, and new perspectives
K Huber - Developmental biology, 2006 - Elsevier
During the past years considerable progress has been made in understanding the
generation of cell diversity in the neural crest (NC). Sympathoadrenal (SA) cells constitute a …
generation of cell diversity in the neural crest (NC). Sympathoadrenal (SA) cells constitute a …
[HTML][HTML] A twist of insight-the role of Twist-family bHLH factors in development
RM Barnes, AB Firulli - The International journal of developmental …, 2009 - ncbi.nlm.nih.gov
Members of the Twist-family of bHLH proteins play a pivotal role in a number of essential
developmental programs. Twist-family bHLH proteins function by dimerizing with other …
developmental programs. Twist-family bHLH proteins function by dimerizing with other …
Enteric neuronal density contributes to the severity of intestinal inflammation
KG Margolis, K Stevanovic, N Karamooz, ZS Li… - Gastroenterology, 2011 - Elsevier
BACKGROUND & AIMS: Enteric neurons have been reported to be increased in inflamed
regions of the bowel in patients with inflammatory bowel disease or intestinal …
regions of the bowel in patients with inflammatory bowel disease or intestinal …
[PDF][PDF] Trunk neural crest cells: formation, migration and beyond
Neural crest cells (NCCs) are a multipotent, migratory cell population that generates an
astonishingly diverse array of cell types during vertebrate development. The trunk neural …
astonishingly diverse array of cell types during vertebrate development. The trunk neural …
BMP signaling regulates sympathetic nervous system development through Smad4-dependent and-independent pathways
Induction of the sympathetic nervous system (SNS) from its neural crest (NC) precursors is
dependent on BMP signaling from the dorsal aorta. To determine the roles of BMP signaling …
dependent on BMP signaling from the dorsal aorta. To determine the roles of BMP signaling …
[HTML][HTML] Hand2 determines the noradrenergic phenotype in the mouse sympathetic nervous system
Y Morikawa, F D'Autréaux, MD Gershon… - Developmental …, 2007 - Elsevier
The basic helix–loop–helix (bHLH) transcription factor Hand2 has been shown to play a role
in the development of the mammalian sympathetic nervous system (SNS); however, its …
in the development of the mammalian sympathetic nervous system (SNS); however, its …
[HTML][HTML] Hand2 is required in the epithelium for palatogenesis in mice
W Xiong, F He, Y Morikawa, X Yu, Z Zhang, Y Lan… - Developmental …, 2009 - Elsevier
The basic helix-loop-helix (bHLH) transcription factor Hand2 has been implicated in the
development of multiple organs, including craniofacial organs. Mice carrying Hand2 …
development of multiple organs, including craniofacial organs. Mice carrying Hand2 …
Transcriptional control of the terminal fate of monoaminergic neurons
N Flames, O Hobert - Annual review of neuroscience, 2011 - annualreviews.org
Monoaminergic neurons are critical functional components of all nervous systems across
phylogeny. The terminally differentiated state of individual types of monoaminergic neurons …
phylogeny. The terminally differentiated state of individual types of monoaminergic neurons …
Expression of Hand2 is sufficient for neurogenesis and cell type–specific gene expression in the enteric nervous system
TJ Hendershot, H Liu, AA Sarkar… - … dynamics: an official …, 2007 - Wiley Online Library
The basic helix‐loop‐helix DNA binding protein Hand2 is expressed in neural crest–derived
precursors of enteric neurons and has been shown to affect both neurogenesis and …
precursors of enteric neurons and has been shown to affect both neurogenesis and …