[HTML][HTML] Neural stem cell grafts form extensive synaptic networks that integrate with host circuits after spinal cord injury
S Ceto, KJ Sekiguchi, Y Takashima, A Nimmerjahn… - Cell stem cell, 2020 - cell.com
Neural stem/progenitor cell (NSPC) grafts can integrate into sites of spinal cord injury (SCI)
and generate neuronal relays across lesions that can provide functional benefit. To …
and generate neuronal relays across lesions that can provide functional benefit. To …
Neuronal activity in the isolated mouse spinal cord during spontaneous deletions in fictive locomotion: insights into locomotor central pattern generator organization
Key points• The organization of the spinal circuitry responsible for the generation of
locomotor rhythm and control of locomotion in mammals is largely unknown, though several …
locomotor rhythm and control of locomotion in mammals is largely unknown, though several …
Functional subpopulations of V3 interneurons in the mature mouse spinal cord
J Borowska, CT Jones, H Zhang… - Journal of …, 2013 - Soc Neuroscience
V3 interneurons (INs) are a major group of excitatory commissural interneurons in the spinal
cord, and they are essential for producing a stable and robust locomotor rhythm. V3 INs are …
cord, and they are essential for producing a stable and robust locomotor rhythm. V3 INs are …
Serotonergic influences on locomotor circuits
U Sławińska, LM Jordan - Current Opinion in Physiology, 2019 - Elsevier
Highlights•Locomotion is associated with activation of descending serotonergic pathways.•A
developmental shift to 5-HT control of afferent input from the moving limb occurs.•Activity …
developmental shift to 5-HT control of afferent input from the moving limb occurs.•Activity …
Modulation of SK channels via calcium buffering tunes intrinsic excitability of parvalbumin interneurons in neuropathic pain: A computational and experimental …
Parvalbumin-expressing interneurons (PVINs) play a crucial role within the dorsal horn of
the spinal cord by preventing touch inputs from activating pain circuits. In both male and …
the spinal cord by preventing touch inputs from activating pain circuits. In both male and …
Molecular and electrophysiological properties of mouse motoneuron and motor unit subtypes
M Manuel, D Zytnicki - Current opinion in physiology, 2019 - Elsevier
Highlights•The development of mouse genetics and transcriptomics has revolutionized the
field of motor control physiology.•We review the efforts made to classify the different …
field of motor control physiology.•We review the efforts made to classify the different …
A gradient in endogenous rhythmicity and oscillatory drive matches recruitment order in an axial motor pool
E Menelaou, DL McLean - Journal of neuroscience, 2012 - Soc Neuroscience
The rhythmic firing behavior of spinal motoneurons is a function of their electrical properties
and synaptic inputs. However, the relative contribution of endogenous versus network …
and synaptic inputs. However, the relative contribution of endogenous versus network …
Role of human-induced pluripotent stem cell-derived spinal cord astrocytes in the functional maturation of motor neurons in a multielectrode array system
The ability to generate human-induced pluripotent stem cell (hiPSC)-derived neural cells
displaying region-specific phenotypes is of particular interest for modeling central nervous …
displaying region-specific phenotypes is of particular interest for modeling central nervous …
Spinal cord injury induces serotonin supersensitivity without increasing intrinsic excitability of mouse V2a interneurons
A Husch, GN Van Patten, DN Hong… - Journal of …, 2012 - Soc Neuroscience
Denervation-induced plastic changes impair locomotor recovery after spinal cord injury
(SCI). Spinal motoneurons become hyperexcitable after SCI, but the plastic responses of …
(SCI). Spinal motoneurons become hyperexcitable after SCI, but the plastic responses of …
Decerebrate mouse model for studies of the spinal cord circuits
The adult decerebrate mouse model (a mouse with the cerebrum removed) enables the
study of sensory-motor integration and motor output from the spinal cord for several hours …
study of sensory-motor integration and motor output from the spinal cord for several hours …