The structural and functional integrity of the ocular surface, a continuous epithelial structure
comprised of the cornea, the conjunctiva, and the ductal surface of the lacrimal as well as …

Conjunctival goblet cells (CGCs) are specialized cells that produce and secrete soluble
mucins to the tear film that bathes the ocular surface. CGC numbers and functions are …

The insights into how genome topology couples with epigenetic states to govern the function
and identity of the corneal epithelium are poorly understood. Here, we generate a high …

Proper differentiation of corneal epithelial cells (CECs) from limbal stem/progenitor cells
(LSCs) is required for maintenance of ocular homeostasis and clear vision. Here, using a …

Purpose: Krüppel-like factor 4 (KLF4) promotes corneal epithelial (CE) cell fate while
suppressing mesenchymal properties. TGF-β plays a crucial role in cell differentiation and …

Purpose: This study aimed to investigate the role and molecular mechanism of ETS1 in the
proliferation and differentiation of human limbal epithelial stem cells (LESCs). Methods: RNA …

In response to corneal injury, an activation of corneal epithelial stem cells and their direct
progeny the early transit amplifying (eTA) cells to rapidly proliferate is critical for proper re …

Purpose: We have observed noticably weak epithelial attachment in vitamin D receptor
knockout mice (VDR KO) undergoing epithelial debridement. We hypothesized that VDR KO …

The corneal epithelium (CE), the most anterior cellular structure of the eye, is a self-
renewing stratified squamous tissue that protects the rest of the eye from external elements …

The cornea is a protective and refractive barrier in the eye crucial for vision. Understanding
the human cornea in health, disease and cell-based treatments can be greatly advanced …