Novel carbon skeletons activate human NicotinAMide Phosphoribosyl Transferase (NAMPT) enzyme in biochemical assay

KH Almeida, L Avalos-Irving, S Berardinelli… - PLoS …, 2023 - journals.plos.org
Nicotinamide adenine dinucleotide (NAD) is a central molecule in cellular metabolism that
has been implicated in human health, the aging process, and an array of human diseases …

Interaction of 2, 6, 7-trihydroxy-xanthene-3-ones with iron and copper, and biological effect of the most active derivative on breast cancer cells and erythrocytes

P Mladěnka, J Karlíčková, M Hrubša, E Veljović… - Applied Sciences, 2020 - mdpi.com
Metal chelators can be potentially employed in the treatment of various diseases, ranging
from metal overload to neoplastic conditions. Some xanthene derivatives were previously …

Modelling of antiproliferative activity measured in HeLa cervical cancer cells in a series of xanthene derivatives

S Zukić, U Maran - SAR and QSAR in Environmental Research, 2020 - Taylor & Francis
Cancer remains one of the leading causes of death in humans, and new drug substances
are therefore being developed. Thus, the anti-cancer activity of xanthene derivatives has …

Analysis of Antitumor Potential of Xanthene Compounds in Lymphoma Cells

E Bilajac, U Glamočlija, A Osmanović… - Croatica chemica …, 2023 - hrcak.srce.hr
Sažetak Antitumor activity of two newly and sixteen previously synthesized 9-arylsubstituted
2, 6, 7-trihydroxyxanthene-3-ones on diffuse large B-cell lymphoma cells were analyzed in …

Effects of newly synthesized xanthene-3-ones on Pseudomonas aeruginosa–Experimental study on rats

A Smajović, E Veljović, M Čelebičić - Veterinaria, 2023 - veterinaria.unsa.ba
The need for new drugs that will have an antimicrobial effect is increasing every day.
Xanthenes are cyclic, organic compounds of natural, semi-synthetic or synthetic origin …

Toxicity testing of newly synthesized xanthene-3-ones after parenteral applications: an experimental study in rats (Rattus norvegicus)

A Smajović, M Katica, D Zavšnik, E Veljović… - Veterinaria, 2020 - veterinaria.unsa.ba
Xanthenes are organic compounds that can be of natural, semi-synthetic and synthetic
origin. Many studies indicate that xanthene and its derivatives have antibacterial, antifungal …

DNA Binding Affinity Assessment of Xanthene Compounds: In Vitro and In Silico Approach

E Veljović, A Osmanović, M Salihović… - Kemija u industriji …, 2023 - hrcak.srce.hr
Sažetak Xanthene derivatives are an important class of heterocyclic compounds with a wide
spectrum of pharmacological activities. In our previous investigations, we found the good …

Quantitative structure–activity relationships of xanthen-3-one and xanthen-1, 8-dione derivatives and design of new compounds with enhanced antiproliferative activity …

S Zukić, S Oljacic, K Nikolic, E Veljović… - Journal of …, 2021 - Taylor & Francis
Xanthene derivatives have become a group of molecules of great importance in discovering
of new anticancer drugs. Recent studies of our group performed on xanthen-3-one and …

Application of Xanten and its derivatives in human and veterinary medicine

A Smajović, M Katica, D Završnik… - Atatürk Üniversitesi …, 2019 - dergipark.org.tr
Xanthene derivatives represent cyclic, organic compounds that can be natural, semi-
synthetic and synthetic origin. These compounds become very interesting because of …

Antimicrobial and Antiproliferative Activities and Enzyme Binding Affinity of Xanthen-3-one Derivatives

E Veljović, A Harej, M Klobučar… - Kemija u industriji …, 2022 - hrcak.srce.hr
Sažetak Ten biologically active derivatives of 2, 6, 7-trihydroxyxanthen-3-one, previously
synthesized and characterised, were investigated for their in vitro antimicrobial and …