Nuclear receptors — a perspective from Drosophila

K King-Jones, CS Thummel - Nature Reviews Genetics, 2005 - nature.com
Nuclear receptors are ancient ligand-regulated transcription factors that control key
metabolic and developmental pathways. The fruitfly Drosophila melanogaster has only 18 …

Molecular mechanisms of developmental timing in C. elegans and Drosophila

CS Thummel - Developmental cell, 2001 - cell.com
Abstract Characterization of the heterochronic genes has provided a strong foundation for
understanding the molecular mechanisms of developmental timing in C. elegans. In …

Steroid hormone induction of temporal gene expression in Drosophila brain neuroblasts generates neuronal and glial diversity

MH Syed, B Mark, CQ Doe - Elife, 2017 - elifesciences.org
An important question in neuroscience is how stem cells generate neuronal diversity. During
Drosophila embryonic development, neural stem cells (neuroblasts) sequentially express …

The ROR nuclear orphan receptor subfamily: critical regulators of multiple biological processes

AM Jetten, E Ueda - 2001 - Elsevier
The nuclear receptor superfamily, a group of structurally related, ligand-dependent
transcription factors, includes a large number of orphan receptors for which no ligand has …

[HTML][HTML] Silencing the HaHR3 gene by transgenic plant-mediated RNAi to disrupt Helicoverpa armigera development

Y Xiong, H Zeng, Y Zhang, D Xu… - International journal of …, 2013 - ncbi.nlm.nih.gov
RNA interference (RNAi) caused by exogenous double-stranded RNA (dsRNA) has
developed into a powerful technique in functional genomics, and to date it is widely used to …

Steroid signaling in plants and insects—common themes, different pathways

CS Thummel, J Chory - Genes & development, 2002 - genesdev.cshlp.org
Drosophila melanogaster. Studies in Arabidopsis have benefited from a detailed description
of the brassinosteroid (BR) biosynthetic pathway, allowing the effects of mutations to be …

Temporal Profiles of Nuclear Receptor Gene Expression Reveal Coordinate Transcriptional Responses during Drosophila Development

AA Sullivan, CS Thummel - Molecular Endocrinology, 2003 - academic.oup.com
The recent completion of the Drosophila genome sequence revealed 21 members of the
nuclear receptor superfamily. Many of these genes are transcriptionally regulated by the …

Molting in C. elegans

V Lažetić, DS Fay - Worm, 2017 - Taylor & Francis
Molting is an essential developmental process for the majority of animal species on Earth.
During the molting process, which is a specialized form of extracellular matrix (ECM) …

Nitric oxide coordinates metabolism, growth, and development via the nuclear receptor E75

L Cáceres, AS Necakov, C Schwartz… - Genes & …, 2011 - genesdev.cshlp.org
Nitric oxide gas acts as a short-range signaling molecule in a vast array of important
physiological processes, many of which include major changes in gene expression. How …

Insect nuclear receptors

SE Fahrbach, G Smagghe… - Annual review of …, 2012 - annualreviews.org
The nuclear receptors (NRs) of metazoans are an ancient family of transcription factors
defined by conserved DNA-and ligand-binding domains (DBDs and LBDs, respectively) …