Diagnosis of neonatal sepsis: the past, present and future

IH Celik, M Hanna, FE Canpolat, M Pammi - Pediatric research, 2022 - nature.com
Sepsis remains a significant cause of neonatal mortality and morbidity, especially in low-and
middle-income countries. Neonatal sepsis presents with nonspecific signs and symptoms …

[HTML][HTML] The effectiveness of metagenomic next-generation sequencing in the diagnosis of prosthetic joint infection: a systematic review and meta-analysis

J Tan, Y Liu, S Ehnert, AK Nüssler, Y Yu… - Frontiers in cellular …, 2022 - frontiersin.org
Background: A prosthetic joint infection (PJI) is a devastating complication following total
joint arthroplasties with poor prognosis. Identifying an accurate and prompt diagnostic …

The role of coagulase-negative staphylococci biofilms on late-onset sepsis: current challenges and emerging diagnostics and therapies

A França - Antibiotics, 2023 - mdpi.com
Infections are one of the most significant complications of neonates, especially those born
preterm, with sepsis as one of the principal causes of mortality. Coagulase-negative …

Current scenario and challenges in the direct identification of microorganisms using MALDI TOF MS

SS Han, YS Jeong, SK Choi - Microorganisms, 2021 - mdpi.com
MALDI TOF MS-based microbial identification significantly lowers the operational costs
because of minimal requirements of substrates and reagents for extraction. Therefore, it has …

SERS-Tags: Selective immobilization and detection of bacteria by strain-specific antibodies and surface-enhanced Raman scattering

M Benešová, S Bernatová, F Mika, Z Pokorná, J Ježek… - Biosensors, 2023 - mdpi.com
Efficient separation and sensitive identification of pathogenic bacterial strains is essential for
a prosperous modern society, with direct applications in medical diagnostics, drug …

Advances in rapid diagnostics for bloodstream infections

N Briggs, S Campbell, S Gupta - Diagnostic Microbiology and Infectious …, 2021 - Elsevier
Septicemia from bloodstream infections (BSI) is the second largest cause of inpatient
mortality and the single most expensive condition for US hospitals to manage. There has …

[HTML][HTML] A prospective evaluation of two rapid phenotypical antimicrobial susceptibility technologies for the diagnostic stewardship of sepsis

C Giordano, E Piccoli, V Brucculeri… - BioMed research …, 2018 - hindawi.com
Rapid identification of bloodstream pathogens by MALDI-TOF MS and the recently
introduced rapid antimicrobial susceptibility testing (rAST) directly from positive blood …

Performance evaluation of the FAST™ System and the FAST-PBC Prep™ cartridges for speeded-up positive blood culture testing

A Verroken, C Hajji, F Bressant, J Couvreur… - Frontiers in …, 2022 - frontiersin.org
Objectives As time to appropriate antimicrobial therapy is major to reduce sepsis mortality,
there is great interest in the development of tools for direct identification (ID) and …

[HTML][HTML] In vitro Activity of Pentamidine Alone and in Combination With Aminoglycosides, Tigecycline, Rifampicin, and Doripenem Against Clinical Strains of …

T Cebrero-Cangueiro, R Álvarez-Marín… - Frontiers in cellular …, 2018 - frontiersin.org
Enterobacteriaceae cause different types of community-and hospital-acquired infections.
Moreover, the spread of multidrug-resistant Enterobacteriaceae is a public health problem …

Direct detection of Staphylococcus aureus in positive blood cultures through molecular beacon-based fluorescence in situ hybridization

B Zhang, Y Maimaiti, C Liu, J Li, H Wang, H Lin… - Journal of …, 2019 - Elsevier
Objective Clinical diagnosis of bloodstream infection diseases depends on the blood culture
results. Bacterial identification by traditional methods is time-consuming. This study aimed to …