Infections with Mycobacterium tuberculosis remain a major cause of disease and death in
humans. Among the factors that contribute to M. tuberculosis's success as a pathogen is its …

Pentacoordinate respiratory hemoproteins such as hemoglobin and myoglobin have
evolved to supply cells with oxygen. However, these respiratory heme proteins are also …

Nitric oxide (NO) is an inevitable product of life in an oxygen-and nitrogen-rich environment.
This reactive diatomic molecule exhibits microbial cytotoxicity, in large part by facilitating …

Nitric oxide and related nitrogen species (reactive nitrogen species) now occupy a central
position in contemporary medicine, physiology, biochemistry, and microbiology. In particular …

Hemoglobins are ubiquitous proteins that sense, store and transport oxygen, but the
physiological processes in which they are implicated is currently expanding. Recent …

Gram-positive bacteria have developed elaborate mechanisms to control ammonium
assimilation, at the levels of both transcription and enzyme activity. In this review, the …

Members of the hemoglobin superfamily efficiently catalyze nitric‐oxide dioxygenation, and
when paired with native electron donors, function as NO dioxygenases (NODs). Indeed, the …

Application of molecular dynamics simulation technique has become a conventional
computational methodology to calculate significant processes at the molecular level. This …

Predicting function from sequence is an important goal in current biological research, and
although, broad functional assignment is possible when a protein is assigned to a family …

Truncated hemoglobins (trHbs) build a sub-class of the globin family, found in eubacteria,
cyanobacteria, unicellular eukaryotes, and in higher plants; among these, selected human …