Heart failure with preserved ejection fraction (HFpEF) affects half of all patients with heart
failure worldwide, is increasing in prevalence, confers substantial morbidity and mortality …

Peroxisome proliferator‐activated receptor‐γ coactivator (PGC)‐1α is a transcriptional
coactivator described as a master regulator of mitochondrial biogenesis and function …

The maintenance of a healthy and functional mitochondrial network is critical during
development as well as throughout life in the response to physiological adaptations and …

Mitochondria with structural and functional integrity are essential for maintaining
mitochondrial function and cardiac homeostasis. It is involved in the pathogenesis of many …

A decline in mitochondrial quality and activity has been associated with normal aging and
correlated with the development of a wide range of age-related diseases. Here, we review …

Traditionally, peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α), a 91 kDa
transcription factor, regulates lipid metabolism and long-chain fatty acid oxidation by …

Pathological molecular mechanisms involved in myocardial remodeling contribute to alter
the existing structure of the heart, leading to cardiac dysfunction. Among the complex …

The regulatory roles of long noncoding RNAs (lncRNAs) in transcriptional coactivators are
still largely unknown. Here, we have shown that the peroxisome proliferator–activated …

The prevalence of obesity, insulin resistance and diabetes is increasing rapidly. Most
patients with these disorders have hypertriglyceridaemia and increased plasma levels of …

Mammalian skeletal muscle comprises different fiber types, whose identity is first established
during embryonic development by intrinsic myogenic control mechanisms and is later …